Diagnosis and antenatal management of congenital cytomegalovirus infection

American Journal of Obstetrics and Gynecology
Society for Maternal- Fetal Medicine (SMFM)Cynthia Gyamfi-Bannerman

Abstract

Congenital cytomegalovirus (CMV) is the most common viral infection, affecting nearly 40,000 infants each year in the United States. Of seronegative women, 1-4% will acquire a primary infection during pregnancy, and the majority of these women will be asymptomatic. Prior maternal exposure to CMV does not preclude neonatal infection. The purpose of this document is to review diagnosis of primary maternal CMV infection, diagnosis of fetal CMV infection, and whether antenatal therapy is warranted. We recommend the following: (1) that women with a diagnosis of primary CMV infection in pregnancy be advised that the risk of congenital infection is 30-50%, on average, and that the severity of infection varies widely (Best Practice); (2) for women suspected of having primary CMV infection in pregnancy, we recommend that diagnosis should be either by IgG seroconversion or with positive CMV IgM, positive IgG, and low IgG avidity (grade 1B); (3) amniocentesis is the best option as a prenatal diagnostic tool to detect fetal congenital CMV infection, performed >21 weeks of gestation and >6 weeks from maternal infection (grade 1C); (4) we do not recommend routine screening of all pregnant women for evidence of primary CMV infection at this t...Continue Reading

References

Mar 5, 1992·The New England Journal of Medicine·K B FowlerC A Alford
Oct 10, 1986·JAMA : the Journal of the American Medical Association·S StagnoC A Alford
Jan 1, 1994·The Pediatric Infectious Disease Journal·D J MorrisV E Newton
Jun 1, 1997·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E B Blau, J R Gross
Nov 5, 1999·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M G RevelloG Gerna
Aug 15, 2000·American Journal of Obstetrics and Gynecology·B GuerraM P Landini
Nov 15, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J Villanueva, E R Garrity
Oct 5, 2002·Clinical Microbiology Reviews·Maria Grazia Revello, Giuseppe Gerna
Aug 14, 2003·The Journal of Pediatrics·David W KimberlinUNKNOWN National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
Apr 2, 2004·The British Journal of Psychiatry. Supplement·UNKNOWN Expert Group
Oct 14, 2004·The Journal of Pediatrics·Stuart P AdlerAl M Best
Sep 10, 2005·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D P PuliyandaS C Jordan
Sep 30, 2005·The New England Journal of Medicine·Giovanni NigroUNKNOWN Congenital Cytomegalovirus Collaborating Group
Dec 22, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Robert F PassSergio Stagno
Feb 24, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Antonia ManouraChristine Giannakopoulou
Jun 21, 2007·Reviews in Medical Virology·Aileen Kenneson, Michael J Cannon
Jul 10, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·F JacquemardY Ville
Dec 7, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Tiziana LazzarottoMaria Paola Landini
Jan 15, 2008·American Journal of Obstetrics and Gynecology·Brunella GuerraNicola Rizzo
Mar 3, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Giovanni Nigro
Jul 9, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marisa M Mussi-PinhataWilliam J Britt
Oct 9, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Christelle Vauloup-FellousLiliane Grangeot-Keros
Dec 1, 2009·Advances in Hematology·Ana ValenciaMiguel A Sanz
Dec 17, 2009·International Journal of Experimental Pathology·Aline Regina Ruiz LimaMarina Politi Okoshi
Jun 3, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T LazzarottoM P Landini
Aug 9, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Gisela EndersMartin Enders
Aug 13, 2011·Journal of Medical Virology·Jutte J C de VriesAnn C T M Vossen
Jan 27, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Manuela FormicaMaria Grazia Revello
Apr 28, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stuart P Adler
Jun 19, 2012·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Ann-Margaret Dunn-NavarraElaine Larson
Apr 19, 2013·BMC Pregnancy and Childbirth·Susan P WalkerMichelle L Giles
Apr 4, 2014·The New England Journal of Medicine·Maria Grazia RevelloUNKNOWN CHIP Study Group
Dec 3, 2014·Obstetrics and Gynecology Clinics of North America·Julie Johnson, Brenna Anderson

❮ Previous
Next ❯

Citations

Apr 27, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yechiel Schlesinger
Apr 12, 2017·Birth Defects Research·Nicole L DavisAthena P Kourtis
Aug 22, 2017·Clinical Pediatrics·Jessica L Coleman, Russell W Steele
Sep 27, 2018·Journal of Tropical Pediatrics·Marcela Fandiño-CárdenasJorge L Alvarado-Socarras
Feb 21, 2019·Journal of Clinical Ultrasound : JCU·Jose R DuncanGiancarlo Mari
Jul 5, 2019·The Medical Journal of Australia·Caitlin L KeighleyGwendolyn L Gilbert
Jan 11, 2018·Clinical Obstetrics and Gynecology·Alexandra Spadola
Dec 6, 2019·Prenatal Diagnosis·Mariana C DiogoDaniela Prayer
Jan 31, 2020·Journal of Clinical Laboratory Analysis·Juanjuan HouPeisong Chen
Feb 20, 2020·Journal of Medical Virology·Anne M SiegelBrenna L Hughes
Mar 22, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anna E DeNobleBrenna L Hughes
May 28, 2020·Prenatal Diagnosis·Marianne Leruez-Ville, Yves Ville
Jun 27, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Indranee N RajapreyarJose Tallaj
May 17, 2017·Archives of Gynecology and Obstetrics·Karl Oliver Kagan, Klaus Hamprecht
Jun 18, 2020·BMC Infectious Diseases·Agathe Billette de VillemeurUNKNOWN French Haut Conseil de la santé publique Working Group
Oct 10, 2020·PloS One·Gail J Demmler-HarrisonUNKNOWN Houston Congenital Cytomegalovirus Longitudinal Study Group
Oct 22, 2020·Developmental Medicine and Child Neurology·Eliza Gordon-LipkinCarlos A Pardo
Oct 31, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marianne Leruez-VilleYves Ville
Apr 28, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M Leruez-VilleY Ville
Sep 17, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·V Faure-Bardon, Y Ville
Jan 2, 2021·Frontiers in Pediatrics·Tulika SinghSallie R Permar
Apr 8, 2020·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Diane W Andronaco
Aug 25, 2020·American Journal of Obstetrics and Gynecology·Clifton O BrockSuneet P Chauhan
Jan 27, 2021·Journal of Genetic Counseling·Robin L PageRyan Loftin
Feb 18, 2017·Deutsches Ärzteblatt International·Horst BuxmannKlaus Friese
Apr 15, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L ZammarchiM Trotta
Feb 7, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Meggie Lallier BeaudoinIsabelle Boucoiran
Feb 13, 2021·Obstetrics and Gynecology Clinics of North America·Sarah C Rogan, Richard H Beigi
Feb 4, 2021·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·V Faure-BardonY Ville
Oct 9, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D BucaF D'Antonio
Mar 1, 2017·Deutsches Ärzteblatt International·Horst BuxmannKlaus Friese
Apr 28, 2021·Mucosal Immunology·Evgeniya V Shmeleva, Francesco Colucci
May 26, 2021·Journal of Midwifery & Women's Health·Megan H PeschSamia Abdelnabi
Jun 6, 2021·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Isabelle BoucoiranEliana Castillo
May 27, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Matthew RosenzweigLiza Johannesson
Jun 26, 2021·American Journal of Obstetrics and Gynecology·UNKNOWN Society for Maternal-Fetal Medicine (SMFM)Joseph R Biggio
Apr 6, 2019·ACS Infectious Diseases·Matthew H Collins, Jesse J Waggoner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.