Abstract
Cytomegalovirus (CMV) infections are common and severe complications of HIV infection. The virus involves the nervous system, causing encephalitis, polyradiculomyelitis and peripheral neuropathies. Due to their limited sensitivity, traditional virological approaches, such as virus isolation or antigen detection in the CSF are useful only in limited instances, e.g. CMV polyradiculopathy. The aetiological diagnosis of these disorders relies on the analysis of cerebrospinal fluid by PCR and quantitative PCR may be important to establish the extent of CNS lesions and to monitor the efficacy of antiviral treatments. CMV is susceptible to various antivirals, including ganciclovir, foscarnet and cidofovir. CMV infections of the nervous system, in particular encephalitis, however, show only a poor response to standard treatments. Drug combination treatments i.e. ganciclovir plus foscarnet, are currently under evaluation in clinical trials.
Citations
Apr 11, 2007·Journal of Neurology·Sahra AbdulleMagnus Gisslén
Feb 5, 2013·Drugs·Marie StudahlElisabeth Aurelius
May 13, 1999·Antiviral Research·T Bergström
Aug 12, 2003·Brain Research Bulletin·C J M SindicS Goffette
Feb 19, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Paola CinqueAke Lundkvist
Jan 22, 2003·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J E JulinH H Balfour
May 15, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P PortegiesP G E Kennedy
Aug 14, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I SteinerUNKNOWN European Neurologic Society
Oct 19, 2004·Clinical Microbiology Reviews·Roberta L Debiasi, Kenneth L Tyler
Mar 7, 2001·Journal of Clinical Microbiology·A BestettiP Cinque
Dec 24, 2009·BMC Neurology·Magnus GisslénHenrik Zetterberg
Jun 5, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·C J SindicS Goffette
May 8, 2002·CNS Drugs·Matthias MaschkeHans-Christoph Diener
Jan 5, 2002·Neurologic Clinics·Joseph R Zunt
Jan 13, 2011·Revista Do Instituto De Medicina Tropical De São Paulo·Camila Almeida SilvaJosé E Vidal
Feb 6, 2004·Revista Do Instituto De Medicina Tropical De São Paulo·José E VidalDiogo L M Lins
Aug 11, 2005·Journal of Neuroimmunology·Paola CinqueRichard W Price
Jan 10, 2016·Current Neurology and Neuroscience Reports·Fritzie Albarillo, Paul O'Keefe
Oct 7, 2018·International Journal of Hematology·Kaito HaradaKazuteru Ohashi
Nov 26, 2019·AIDS·Tommaso LupiaAndrea Calcagno