Diagnosis and individualized therapy of neoplastic meningitis

Expert Review of Anticancer Therapy
H Strik, P Prömmel

Abstract

Neoplastic meningitis is a diffuse dissemination of tumor cells into the cerebrospinal fluid (CSF) and/or leptomeninges. It occurs in approximately 5-10% of malignant diseases, most often in breast cancer, lung cancer, melanoma or B-cell lymphoma. Symptoms of neoplastic meningitis are head or back pain, cranial nerve palsies, diffuse radicular symptoms or psychiatric disturbances. MRI shows nodular contrast enhancement lining CSF spaces. Positive CSF cytology requires optimal sampling and processing. Treatment must be individually shaped: the CSF dissemination may be treated with intrathecal chemotherapy with methotrexate or cytarabinoside (Ara-C). Liposomal Ara-C is distributed over the entire CSF space even after lumbar application and maintains cytotoxic levels for at least 2 weeks. Radiotherapy should be applied only to symptomatic solid spinal manifestations or fast progressing cranial nerve palsies. Systemic chemotherapy is needed to control solid manifestations or, in the case of substances entering the CSF, to support intrathecal chemotherapy.

References

Jan 1, 1978·Medical and Pediatric Oncology·D A ShepherdD J Fernbach
Mar 1, 1988·Neurology·H I SchipperK Felgenhauer
Oct 11, 1973·The New England Journal of Medicine·W A BleyerB A Chabner
Jan 1, 1981·Cancer·D J StewartE J Freireich
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S A GrossmanD S Ettinger
Jul 1, 1996·Archives of Neurology·M Balm, J Hammack
Aug 8, 1998·Journal of Neuro-oncology·N Gökbuget, D Hoelzer
Aug 8, 1998·Journal of Neuro-oncology·L M DeAngelis
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J GlantzS B Howell
May 3, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D CrivellariUNKNOWN International Breast Cancer Study Group
Oct 13, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N Pavlidis
Jan 8, 2005·Seminars in Neurology·Marc C Chamberlain
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc C Chamberlain
Jun 13, 2006·Journal of the Neurological Sciences·Joachim M BaehringJeffrey Sklar
Feb 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James L RubensteinMarc Shuman
Oct 25, 2008·Arquivos de neuro-psiquiatria·Sérgio Monteiro de AlmeidaMargaret Ono
Mar 24, 2009·Critical Reviews in Oncology/hematology·Alba A BrandesRolf D Kortmann

❮ Previous
Next ❯

Citations

Mar 26, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·P GavianiA Silvani
Apr 22, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Julia IllánDolores Subirá
Mar 22, 2014·Molecular and Clinical Oncology·Koichi KurishimaHiroaki Satoh
Aug 16, 2017·Fluids and Barriers of the CNS·Catharina ConradJörg W Bartsch
Feb 9, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Georgios RigakosEvangelia Razis

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.