Diagnosis and inflammatory response of patients with candiduria.

Mycoses
S HelbigB C Fries

Abstract

Candiduria is common in hospitalised patients, but the clinical relevance is still unclear. This study was done to further our knowledge on detection of and host responses to candiduria. Urines and clinical data from 136 patients in whom presence of yeast was diagnosed by microscopic urinalysis were collected. Diagnosis by standard urine culture methods on blood and MacConkey agar as well as on fungal culture medium (Sabouraud dextrose agar) was compared. Inflammatory parameters (IL-6 and IL-17, Ig) were quantified in the urine and compared with levels in control patients without candiduria. Standard urine culture methods detected only 37% of Candida spp. in urine. Sensitivity was especially low (23%) for C. glabrata and was independent of fungal burden. Candida specific IgG but not IgA was significantly elevated when compared with control patients (P < 0.0001 and 0.07 respectively). In addition, urine levels of IL-6 and IL-17 were significantly higher in candiduric patients when compared with control patients (P < 0.001). Multivariate analysis documented an independent association between an increased IgG (odds ratio (OR) 136.0, 95% confidence interval (CI) 25.7-719.2; P < 0.0001), an increased IL-17 (OR 17.4, 95% CI 5.3-57.0;...Continue Reading

References

Nov 1, 1989·Infection and Immunity·P de ManC Svanborg Edén
Oct 1, 1966·Sabouraudia·D G AhearnF J Roth
Oct 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B S AngW R Wilson
May 4, 1999·Infection and Immunity·L C ChenA Casadevall
Jul 8, 1999·International Journal of Antimicrobial Agents·J D Sobel
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A KauffmanW E Dismukes
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J D SobelW E Dismukes
Sep 1, 2000·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·M J RichardsR P Gaynes
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G GodalyC Svanborg
Dec 18, 2001·The Journal of Biological Chemistry·Indira U MysorekarJeffrey I Gordon
May 21, 2003·Intensive Care Medicine·Francisco Alvarez-LermaUNKNOWN EPCAN Study Group
Jan 21, 2004·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Monica SlavinWilliam C Gerth
Jul 10, 2004·The Journal of Infectious Diseases·Weitao HuangPaul Schwarzenberger
Apr 22, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N SafdarD Andes
Jan 31, 2007·Applied and Environmental Microbiology·N JainB C Fries
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masayuki UmemuraGoro Matsuzaki
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kensuke ShibataYasunobu Yoshikai
Aug 21, 2007·Current Opinion in Microbiology·Alistair J P BrownNeil A R Gow
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Justin HartupeeThomas Hamilton
Sep 28, 2007·European Journal of Immunology·Teresa ZelanteLuigina Romani
Dec 7, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S C A ChenT C Sorrell
Dec 22, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R ColodnerR Raz
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvia BozzaLuigina Romani
Jun 20, 2008·Nature·Estelle BettelliVijay K Kuchroo
Jul 9, 2008·Medical Mycology·Teresa ZelanteLuigina Romani
Aug 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Satoru HamadaGoro Matsuzaki
Feb 5, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasUNKNOWN Infectious Diseases Society of America
Feb 11, 2009·The Journal of Experimental Medicine·Heather R ContiSarah L Gaffen
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiromasa HamadaRichard W Dutton
Mar 19, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew CopeBarbara W Trautner
Apr 22, 2009·Cell Host & Microbe·Frank L van de VeerdonkMihai G Netea
Jan 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kelsey E SivickHarry L T Mobley
Apr 22, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carol A KauffmanCheryl A Newman

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Sep 4, 2014·Infection and Immunity·Jeniel E NettDavid R Andes

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