Diagnosis and Management of Autoimmune Dementia

Current Treatment Options in Neurology
Elia Sechi, Eoin P Flanagan

Abstract

To describe the clinical, laboratory, and MRI features that characterize cognitive decline in the setting of central nervous system (CNS) autoimmunity, and provide an overview of current treatment modalities. The field of autoimmune neurology is rapidly expanding due to the increasing number of newly discovered autoantibodies directed against specific CNS targets. The clinical syndromes associated with these autoantibodies are heterogeneous but frequently share common, recognizable clinical, and MRI characteristics. While the detection of certain autoantibodies strongly suggest the presence of an underlying malignancy (onconeural autoantibodies), a large proportion of cases remain idiopathic. Cognitive decline and encephalopathy are common manifestations of CNS autoimmunity, and can mimic neurodegenerative disorders. Recent findings suggest that the frequency of autoimmune encephalitis in the population is higher than previously thought, and potentially rivals that of infectious encephalitis. Moreover, emerging clinical scenarios that may predispose to CNS autoimmunity are increasingly been recognized. These include autoimmune dementia/encephalitis post-herpes simplex virus encephalitis, post-transplant and in association with ...Continue Reading

References

May 6, 2003·Annals of Neurology·Sean J PittockVanda A Lennon
Jun 25, 2004·Brain : a Journal of Neurology·Josep DalmauMyrna R Rosenfeld
Oct 7, 2004·Annals of Neurology·Sean J PittockVanda A Lennon
Jun 29, 2005·Annals of Neurology·Sean J PittockVanda A Lennon
Sep 15, 2006·Mayo Clinic Proceedings·Sean J PittockVanda A Lennon
Oct 15, 2008·Archives of Neurology·Michael D GeschwindSean J Pittock
Apr 2, 2009·Annals of Neurology·Meizan LaiJosep Dalmau
Oct 5, 2010·Mayo Clinic Proceedings·Eoin P FlanaganSean J Pittock
Oct 19, 2010·The Lancet Infectious Diseases·Julia GranerodUNKNOWN UK Health Protection Agency (HPA) Aetiology of Encephalitis Study Group
Dec 15, 2010·Archives of Neurology·Enrique Aradillas, Robert J Schwartzman
Dec 29, 2010·Journal of Neurology·Sarah JesseMarkus Otto
Mar 19, 2011·Annals of Neurology·Sarosh R IraniAngela Vincent
Sep 22, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Carsten FinkeChristoph J Ploner
Nov 15, 2011·Journal of Neurology·Caroline ReyMathieu Ceccaldi
Jan 28, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mary S GableCarol A Glaser
Oct 24, 2012·JAMA Neurology·Andrew McKeonJosep Dalmau
Aug 9, 2013·Neurology·Oliver J JefferyAndrew McKeon
Aug 15, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·B OyangurenI Corral
Apr 5, 2014·Annals of Neurology·Maarten J TitulaerJosep Dalmau
May 17, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Erika S HortaSean J Pittock
Jun 15, 2014·Journal of the Neurological Sciences·Monika SzotsZsolt Illes
Jun 22, 2014·Brain : a Journal of Neurology·Alexander Carvajal-GonzálezAngela Vincent
Oct 14, 2014·International Journal of Rheumatic Diseases·Eoin P FlanaganNeeraj Kumar

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Citations

Apr 22, 2020·Proceedings·Smathorn ThakolwiboonParunyou Julayanont
Dec 5, 2020·Continuum : Lifelong Learning in Neurology·Eoin P Flanagan
Nov 15, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Elia Sechi, Anastasia Zekeridou
Apr 3, 2021·Therapeutic Advances in Neurological Disorders·Samantha A BanksEoin P Flanagan
Jul 3, 2021·Frontiers in Psychiatry·Niels HansenCharles Timäus

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