Diagnosis and management of clinical and subclinical cobalamin deficiency: advances and controversies

Current Hematology Reports
R Carmel, Mona Sarrai

Abstract

Major recent developments in cobalamin deficiency include issues such as the nature of food-cobalamin malabsorption, sensitivities and specificities of diagnostic tests, and emerging data on oral therapy. These have been heavily influenced by studies of subclinical deficiency, which has a much slower progression (which may be nonlinear), arises from different causes, and poses different, more public health-oriented management considerations than the less frequent but much more medically important entity of clinically expressed deficiency. Distinguishing carefully between the two deficiency states is helpful because clinical lessons and strategies derived from one may not apply equally to the other, as illustrated by controversial decisions about clinical issues such as the serum cobalamin level diagnostic of deficiency. Reassessment of diagnostic and management approaches, including improving our ability to diagnose cobalamin malabsorption, is required.

References

Jan 1, 1979·The American Journal of the Medical Sciences·R E SamplinerJ Boitnott
Dec 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H AdachiK Kobayashi
Mar 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H Y HsuD S Chen
Jul 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A MasonR P Perrillo
Apr 15, 1991·Annals of Internal Medicine·J KorenmanJ H Hoofnagle
Jan 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M C YuS Govindarajan
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L MasonR P Perrillo
Jul 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T I HuoS D Lee
Aug 10, 1999·Journal of Medical Virology·P F ColemanI K Mushahwar
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H IrelandW F Carman
Jun 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C BréchotP Paterlini-Bréchot
Jun 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H S Conjeevaram, A S Lok
Dec 31, 2003·Lancet·Ching Lung LaiThierry Poynard
Jun 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Man-Fung YuenChing-Lung Lai
Oct 9, 2004·Journal of Clinical Microbiology·Man-Fung YuenChing-Lung Lai

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Citations

Nov 8, 2008·QJM : Monthly Journal of the Association of Physicians·N Dali-Youcef, E Andrès
Oct 20, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·D J VanderjagtR H Glew
Jan 1, 2008·Current Gerontology and Geriatrics Research·Emmanuel AndrèsGeorges Kaltenbach
Jan 14, 2012·Current Opinion in Gastroenterology·Ralph Carmel
Jul 1, 2017·Nature Reviews. Disease Primers·Ralph GreenChittaranjan Yajnik
Apr 9, 2011·International Journal of Hematology·Angel F RemachaJorge Cuesta
Oct 27, 2020·Journal of Central Nervous System Disease·Fuad Al Mutairi

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