PMID: 20635783Jul 20, 2010Paper

Diagnosis and management of immunodeficiencies in adults by allergologists

Journal of Investigational Allergology & Clinical Immunology
J M GarcíaCommittee of Immunology of the Spanish Socierty of Allergology and Clinical Immunology

Abstract

Primary immunodeficiencies (PIDs) are genetic diseases that cause alterations in the immune response and occur with an increased rate of infection, allergy, autoimmune disorders, and cancer. They affect adults and children, and the diagnostic delay, morbidity, effect on quality of life, and socioeconomic impact are important. Therapy (gamma-globulin substitution in most cases) is highly effective. We examine adult PIDs and their clinical presentation and provide a sequential and directed framework for their diagnosis. Finally, we present a brief review of the most important adult PIDs, common variable immunodeficiency, including diagnosis, pathogenesis, clinical signs, and disease management.

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