Diagnosis and management of infants with congenital cytomegalovirus infection

Paediatrics & Child Health
Soren GanttWendy Vaudry

Abstract

Congenital cytomegalovirus infection (cCMV) is the most common congenital infection, occurring in approximately 0.5% of live births. Most infected newborns are asymptomatic, but up to 20% develop sensorineural hearing loss or other permanent neurologic sequelae. The presentation of newborns with symptomatic cCMV is highly variable, and the infection is usually not diagnosed in the absence of a screening program. Newborn cCMV screening programs are estimated to be beneficial and cost-effective, and are increasingly being implemented. Diagnosis requires direct detection of virus in a sample obtained before 3 weeks of life, and is best performed by polymerase chain reaction (PCR) of saliva or urine, either of which is more sensitive than dried blood spot. Antiviral treatment of selected newborns with cCMV-related disease appears to improve hearing and neurocognitive outcomes. All infected infants should be evaluated promptly to determine appropriate therapy, and receive close audiologic and developmental follow-up.

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Citations

Jan 24, 2020·Journal of Clinical Microbiology·Soren GanttLawrence M Mertz
Apr 26, 2018·Frontiers in Pediatrics·Raidan AlyazidiSoren Gantt
Jul 17, 2019·The Journal of Infectious Diseases·Smadar Eventov-FriedmanDana G Wolf
Dec 11, 2019·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mina SmiljkovicFatima Kakkar
Mar 27, 2021·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Yulia ShlonskyOrit Golan-Shany
Jun 5, 2021·BMJ : British Medical Journal·Megan H PeschJason B Weinberg
Jun 6, 2021·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Isabelle BoucoiranEliana Castillo
Aug 7, 2021·Clinics in Perinatology·Tina A Leone, Wanda J Abreu

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