Abstract
Congenital cytomegalovirus infection (cCMV) is the most common congenital infection, occurring in approximately 0.5% of live births. Most infected newborns are asymptomatic, but up to 20% develop sensorineural hearing loss or other permanent neurologic sequelae. The presentation of newborns with symptomatic cCMV is highly variable, and the infection is usually not diagnosed in the absence of a screening program. Newborn cCMV screening programs are estimated to be beneficial and cost-effective, and are increasingly being implemented. Diagnosis requires direct detection of virus in a sample obtained before 3 weeks of life, and is best performed by polymerase chain reaction (PCR) of saliva or urine, either of which is more sensitive than dried blood spot. Antiviral treatment of selected newborns with cCMV-related disease appears to improve hearing and neurocognitive outcomes. All infected infants should be evaluated promptly to determine appropriate therapy, and receive close audiologic and developmental follow-up.
References
Dec 1, 1983·The Journal of Infectious Diseases·R F PassC A Alford
Jun 1, 1994·The Journal of Infectious Diseases·J Troendle AtkinsG J Buffone
Jul 6, 2000·The Pediatric Infectious Disease Journal·D E NoyolaM D Yow
Mar 10, 2001·The Journal of Pediatrics·D E NoyolaUNKNOWN Houston Congenital CMV Longitudinal Study Group
Aug 14, 2003·The Journal of Pediatrics·David W KimberlinUNKNOWN National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
Dec 21, 2004·The Journal of Infectious Diseases·Russell D BradfordUNKNOWN National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
Oct 3, 2007·Pediatrics·UNKNOWN American Academy of Pediatrics, Joint Committee on Infant Hearing
Apr 15, 2010·JAMA : the Journal of the American Medical Association·Suresh B BoppanaUNKNOWN National Institute on Deafness and Other Communication Disorders CMV and Hearing Multicenter Screening (CHIMES) Study
Jun 3, 2011·The New England Journal of Medicine·Suresh B BoppanaUNKNOWN National Institute on Deafness and Other Communication Disorders CHIMES Study
Jul 4, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Teresa del RosalJavier Vilas
Apr 17, 2013·The Journal of Pediatrics·Ana AlarconAlfredo Garcia-Alix
Dec 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Suresh B BoppanaKaren B Fowler
Nov 28, 2013·Clinical Pediatrics·Jacob AmirJoseph Pardo
Dec 19, 2013·The Pediatric Infectious Disease Journal·Amanda GweeAndrew J Daley
Apr 8, 2014·Archives of Disease in Childhood·Amanda GweeAndrew J Daley
Apr 25, 2014·Reviews in Medical Virology·Michael J CannonWilliam D Rawlinson
Oct 29, 2014·Pediatrics·Julie GoderisIngeborg Dhooge
Nov 13, 2014·The Journal of Infectious Diseases·Gabriella FornerNadia Gussetti
Mar 5, 2015·The New England Journal of Medicine·David W KimberlinUNKNOWN National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
Mar 13, 2015·Medical Microbiology and Immunology·William Britt
May 23, 2015·Pediatric Annals·Gail J Harrison
Oct 4, 2015·International Journal of Pediatric Otorhinolaryngology·Anna BergevinAlbert H Park
Nov 26, 2015·The Journal of Pediatrics·Brendan SorichettiSoren Gantt
Citations
Jan 24, 2020·Journal of Clinical Microbiology·Soren GanttLawrence M Mertz
Jun 22, 2019·BMC Pregnancy and Childbirth·Yuka ToriiYoshinori Ito
Jun 7, 2019·BMC Pediatrics·Mina SmiljkovicFatima Kakkar
Apr 26, 2018·Frontiers in Pediatrics·Raidan AlyazidiSoren Gantt
Jul 17, 2019·The Journal of Infectious Diseases·Smadar Eventov-FriedmanDana G Wolf
Dec 11, 2019·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mina SmiljkovicFatima Kakkar
Mar 27, 2021·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Yulia ShlonskyOrit Golan-Shany
Jun 5, 2021·BMJ : British Medical Journal·Megan H PeschJason B Weinberg
Jun 6, 2021·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Isabelle BoucoiranEliana Castillo
Aug 7, 2021·Clinics in Perinatology·Tina A Leone, Wanda J Abreu
Nov 24, 2021·Journal of Clinical Laboratory Analysis·Canyang ZhanLihua Chen