Diagnosis and management of persistent pulmonary hypertension of the newborn

Paediatric Respiratory Reviews
Perraju BendapudiAnne Greenough

Abstract

Persistent pulmonary hypertension of new born (PPHN) is associated with mortality and morbidity; it may be idiopathic or secondary to a number of conditions. The mainstay of diagnosis and to exclude structural abnormalities is echocardiography. Brain type natriuretic peptide (BNP) levels are elevated in PPHN, but are insufficiently sensitive to contribute to routine diagnosis. Management includes improving oxygenation by optimising lung volume by ventilatory techniques and/or surfactant and administering pulmonary vasodilator agents. Inhaled nitric oxide (iNO), a selective pulmonary vasodilator, reduces the need for extracorporeal membrane oxygenation in term infants; it does not, however, improve mortality or have any long term positive effects in prematurely born infants or infants with congenital diaphragmatic hernia. Other pulmonary vasodilators have been reported in case series to be efficacious alone or in combination with iNO. Randomised trials with long term follow up are required to identify the optimum therapeutic strategies in PPHN.

References

Feb 1, 1995·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M RespondekJ C Huhta
Jul 28, 1999·Anesthesiology·A M Atz, D L Wessel
Apr 24, 2001·Pharmacology & Therapeutics·B WeinbergerJ D Laskin
May 30, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·Reese H ClarkUNKNOWN Clinical Inhaled Nitric Oxide Research Group
Dec 31, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Cho NgAndy Petros
Sep 13, 2005·Biology of the Neonate·Dirk BasslerHaresh Kirpalani
Apr 26, 2006·Pediatrics·Helena McNallyUNKNOWN UK Collaborative ECMO Trial Group
May 4, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Eric Wooltorton
Jun 2, 2006·The Journal of Pediatrics·Paola J FlimanRobin H Steinhorn
Jun 14, 2006·Journal of Critical Care·Patrick J McNamaraHilary E Whyte
Aug 19, 2006·American Journal of Respiratory and Critical Care Medicine·Poongundran NamachivayamLara S Shekerdemian
Feb 20, 2007·The Journal of Pediatrics·G Ganesh KonduriUNKNOWN Neonatal Inhaled Nitric Oxide Study Group
Aug 3, 2007·Pediatrics·Sonia Hernández-DíazAllen A Mitchell
Aug 19, 2007·American Journal of Respiratory and Critical Care Medicine·Enrica FornaroJaques Belik
Mar 5, 2008·Pharmacoepidemiology and Drug Safety·Bengt Källén, Petra Otterblad Olausson
Mar 8, 2011·European Journal of Pediatrics·Maurizio RadicioniPiergiorgio Camerini
Nov 30, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Ellen A NohrSven Cnattingius
May 21, 2013·Jornal de pediatria·Joaquim E B Cabral, Jaques Belik
Oct 3, 2013·Early Human Development·Robin H Steinhorn

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Citations

Jan 19, 2016·Seminars in Perinatology·Satyan LakshminrusimhaCorinne L Leach
Jan 20, 2016·NeoReviews·Satyan Lakshminrusimha, Martin Keszler
Sep 9, 2015·Pediatric Pulmonology·Montaha M Al-IedeDominic A Fitzgerald
Jun 1, 2015·Paediatric Respiratory Reviews·Charles Christoph Roehr, Kajsa Bohlin
Mar 13, 2016·Pediatric Pulmonology·Kai KönigCharles P Barfield
Jun 2, 2018·Basic & Clinical Pharmacology & Toxicology·Jonas PedersenDaniela Grimm
Aug 4, 2018·Pediatric Research·Willem P de BoodeUNKNOWN European Special Interest Group ‘Neonatologist Performed Echocardiography’ (NPE)
Sep 22, 2017·Maternal Health, Neonatology and Perinatology·Deepak Sharma
Aug 2, 2019·Journal of Paediatrics and Child Health·Joshua AhearnTejasvi Chaudhari
Oct 16, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Narongsak NakwanPoom Woei Bing
Mar 17, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Deepak SharmaPradeep Sharma
Aug 5, 2020·European Journal of Pediatrics·Masashi ZuikiHiroshi Komatsu
Jul 21, 2020·Journal of Health Economics and Outcomes Research·Shivani PandyaLi Wang
Apr 6, 2021·Global Pediatric Health·Myriam Almeida-JonesRuchira Garg

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