Diagnosis and neurocognitive profiles in first-episode non-affective psychosis patients

European Archives of Psychiatry and Clinical Neuroscience
Rosa Ayesa-ArriolaBenedicto Crespo-Facorro

Abstract

This study explored whether there are distinguishable neurocognitive profiles in diagnostic subgroups of first-episode non-affective psychosis (FEP) patients. Four hundred and eighty-seven individuals with diagnoses of non-affective psychosis disorders were evaluated 6 months after first contact with psychiatric services. Individuals with schizophrenia (n = 257), schizophreniform (n = 141), brief psychotic disorder (n = 54), and psychosis not otherwise specified (n = 35) were compared on baseline neuropsychological variables using analyses of variance and covariance with potential clinical, premorbid, and sociodemographic confounders. The brief psychotic disorder subgroup was the least impaired on global cognitive function, in particular when compared to the schizophrenia subgroup, and specifically on executive function, processing speed, and motor dexterity domains. However, with the exception of the processing speed domain, profile differences could be explained by sex, age, psychotic and negative symptoms, years of education, and premorbid IQ. These results suggest processing speed as a diagnostic marker for brief psychotic disorder in FEP patients. Further, there are quantitative and qualitative differences across the schiz...Continue Reading

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Citations

Aug 6, 2019·Acta Psychiatrica Scandinavica·E Setién-SueroR Ayesa-Arriola
Aug 2, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·A C Castagnini, P Fusar-Poli
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Apr 4, 2021·European Archives of Psychiatry and Clinical Neuroscience·María José Valdés-FloridoMiguel Ruiz-Veguilla

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