Diagnosis and outcome of 100 consecutive patients with extreme granulocytic leukocytosis

The American Journal of Medicine
M T RedingG A Filice

Abstract

To determine the clinical features, causes, and prognostic significance of extreme leukocytosis in adults. Medical records of 100 consecutive patients who presented at the Minneapolis Veterans Affairs Medical Center between March 1993 and January 1994 with more than 25,000 leukocytes/microL blood and with more than 50% granulocytes were reviewed. Demographic, clinical, and outcome information was recorded, and a cause of extreme leukocytosis was sought in each case. Extreme leukocytosis was attributed to infection in 48 cases, advanced malignancy in 13 cases, hemorrhage in 9 cases, glucocorticoids in 8 cases, and other causes in 22 cases. Four patients had previously diagnosed conditions resulting in chronic leukocytosis. Higher leukocyte counts were associated with malignancy (chi2 for trend=12.5, P <0.002). Fever was more common in patients with infection (weighted rate ratio=3.7, 95% Confidence interval [CI]=2.2 to 6.2). Mortality was high overall (31%), and was greater in patients with noninfectious diagnoses compared with infected patients, an association which persisted after stratification by leukocyte count (weighted rate ratio=2.5, 95% CI=1.2 to 4.9). Clinicians should be aware that extreme leukocytosis with a predomin...Continue Reading

References

Apr 1, 1992·Journal of Psychiatric Research·M MaesP Cosyns
Feb 1, 1991·Southern Medical Journal·R G MitchellD Sandidge
Nov 1, 1989·Disease-a-month : DM·R A Johnson, G D Roodman
Apr 1, 1987·Archives of Internal Medicine·J W MellorsS M Horwitz
Oct 11, 1985·JAMA : the Journal of the American Medical Association·R H GrimmW Ludwig
Feb 1, 1984·The Thoracic and Cardiovascular Surgeon·J MiholicE Domanig
Feb 1, 1984·Surgical Neurology·D Parkinson, S Stephensen
Jan 1, 1980·Postgraduate Medicine·P C Ward
Feb 19, 1981·The New England Journal of Medicine·J B ZalokarJ R Claude
Jan 1, 1994·Acta neurochirurgica·S KeskilS Aykol
Jul 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D A Talan
Sep 10, 1953·The New England Journal of Medicine·S V HILTS, C C SHAW
Nov 29, 1954·The Journal of Physiology·W I CRANSTONE S SNELL

❮ Previous
Next ❯

Citations

Jan 9, 2010·QJM : Monthly Journal of the Association of Physicians·K AsadollahiG V Gill
Mar 31, 2001·Journal of the American Veterinary Medical Association·M D Lucroy, B R Madewell
May 29, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anna WanahitaDaniel M Musher
Sep 3, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Israel Potasman, Moti Grupper
Feb 5, 2011·La Revue de médecine interne·J Deibener-KaminskyP Kaminsky
Jun 15, 2011·Emergency Medicine Australasia : EMA·Khairollah AsadollahiNicholas J Beeching
Apr 2, 2016·La Revue de médecine interne·C E LavoignetP Bilbault
Feb 22, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yaowalark SukthanaSomsit Tansuphaswasdikul
Jul 24, 2008·Journal of Cancer Survivorship : Research and Practice·Emily SchulzHope Lawrence
Nov 26, 2019·International Journal of Laboratory Hematology·Júlia P Portich, Gustavo A M Faulhaber
Sep 29, 2015·Pediatric Emergency Care·Laura K GonzalezElka Jacobson-Dickman
Apr 27, 2018·European Journal of Pediatrics·Assaf HoofienGilat Livni
Jan 12, 2021·The Journal of International Medical Research·Huang Hongwei
Dec 29, 2020·Clinical Case Reports·Emily BinghamMichael Schaer
Mar 14, 2019·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Stamatis KarakonstantisCharalampos Lydakis

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