Diagnosis and screening for cytomegalovirus infection in pregnant women in Cuba as prognostic markers of congenital infection in newborns: 2007-2008

The Pediatric Infectious Disease Journal
Vivian KouríPierrette Melin

Abstract

Human cytomegalovirus (HCMV) has established itself as the most significant cause of congenital infection in the developed world. The objective of this research was prenatal identification of pregnant women at risk for developing active infection due to HCMV as well as to diagnose congenitally infected newborns. A diagnostic algorithm based on specific immunoglobulin G (IgG), IgM, and, IgG avidity was used to screen serum from 1131 pregnant women enrolled prospectively from 3 municipalities from Havana City, Cuba during 2007-2008. Qualitative multiplex nested PCR and quantitative real time-based PCR testing for HCMV DNA were performed on urine and saliva specimens from women detected with active infection and from their newborns. Most women were seropositive to HCMV (92.7%), with 2.38% (27 women) having active infection. Primary infection was detected in 20 pregnant women (1.77%) while 7 patients (0.62%) had active nonprimary infection. HCMV DNA was detected in specimens from 9 of the 27 pregnant women by both PCR methods. HCMV congenital infection was diagnosed in 12 (1.06%) of the 26 live children born from 25 mothers with active infection, for a vertical transmission rate of 46.2%. Two fetal deaths were reported from 2 women...Continue Reading

References

Oct 1, 1993·Journal of Virological Methods·A TenorioE Tabarés
Apr 1, 1997·The Journal of Infectious Diseases·L Grangeot-KerosE Dussaix
Dec 29, 1986·Physical Review Letters·G G Cabrera, R Jullien
Mar 12, 1999·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M Bodéus, P Goubau
Jun 24, 1999·Journal of Perinatal Medicine·A CasteelsW Foulon
May 3, 2001·The New England Journal of Medicine·S B BoppanaW J Britt
Jun 12, 2001·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M BodéusP Goubau
Oct 5, 2002·Clinical Microbiology Reviews·Maria Grazia Revello, Giuseppe Gerna
Aug 26, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·Y SchlesingerD Miron
Nov 3, 2004·International Journal of Antimicrobial Agents·Atef KanaanJuan J Picazo
Jan 4, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Changpin ZhangRobert F Pass
Jun 6, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Aparecida Yulie YamamotoThalita Bonadio Coelho
Oct 13, 2006·Audiology & Neuro-otology·Satoshi IwasakiHiroyuki Mineta
Oct 13, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Regan N TheilerDenise J Jamieson
Feb 20, 2007·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·D EstripeautX Sáez-Llorens
Mar 17, 2007·Scandinavian Journal of Infectious Diseases·Sabahattin OcakArif Gungoren
Sep 15, 2007·Journal of Paediatrics and Child Health·Mei-Huei ChenWu-Shiun Hsieh
Oct 25, 2007·Gynecologic and Obstetric Investigation·Jian-Ping ZhangXin-Wen Zhang
Oct 26, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Scott D GrosseSheila C Dollard
Dec 7, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Tiziana LazzarottoMaria Paola Landini
Jan 15, 2008·American Journal of Obstetrics and Gynecology·Brunella GuerraNicola Rizzo
May 20, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·L GindesG Rahav
Jun 17, 2008·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Roberta Maia de Castro RomanelliFrançois Jacquemard
Apr 8, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mojgan Tabatabaee, Dariush Tayyebi
Jun 2, 2009·The Pediatric Infectious Disease Journal·Lauren Stancik RosenthalMichael J Cannon
Jul 9, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marisa M Mussi-PinhataWilliam J Britt

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Citations

Jan 9, 2013·Clinical Microbiology Reviews·Sheetal ManicklalRavindra K Gupta
Jun 17, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·C CorreaC Limia
Dec 21, 2013·European Journal of Immunology·Anke RedekerRamon Arens
Jun 26, 2017·GeroScience·Sarah E JacksonMark R Wills
Aug 29, 2014·Clinical and Vaccine Immunology : CVI·Harry E Prince, Mary Lapé-Nixon
May 1, 2013·Immunity & Ageing : I & a·Beatriz García VerdeciaAgustín Lage Dávila
Aug 10, 2013·Pathogens and Disease·Wioletta WujcickaDorota Nowakowska
Mar 7, 2017·Frontiers in Immunology·Danay SaavedraAgustin Lage

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