PMID: 6159291Oct 2, 1980Paper

Diagnosis and therapy of multiple sclerosis

Fortschritte der Medizin
H Woelk, I Neu

Abstract

The diagnosis of multiple sclerosis is still a clinical one, and depends on the occurrence of neurological symptoms due to lesions at two or more necessarily distinct sites in the white matter of the central nervous system. Up to now there exists no specific laboratory test for the diagnosis of multiple sclerosis. The cerebrospinal fluid-profile strongly supporting the diagnosis of multiple sclerosis consists of: cell count slightly elevated, total protein concentration normal or slightly elevated, in the electrophoresis distinct immunreaction without disturbance of the blood-brain-barrier, i.e. significant increase of gammaglobulins and IgG, oligoclonal pattern of the gammaglobulin subfractions. Newly developed diagnosistic possibilities are based on the determination of myelin basic protein, determination of the different glycerophosphatides and on the measurement of the activity of lipid hydrolyzing enzymes. Disturbances of lipid metabolism play an important role in the course of demyelination. Therapy of multiple sclerosis by steroids and immunsuppression will be discussed.

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Schweizer Archiv für Neurologie und Psychiatrie = Archives suisses de neurologie et de psychiatrie = Archivio svizzero di neurologia e psichiatria : offizielles Organ der Schweizerischen Neurologischen Gesellschaft und der SchweizerischenGesellschaft für
R M SchmidtV Neumann
Critical Reviews in Clinical Laboratory Sciences
P D Mehta
Journal of Neurology, Neurosurgery, and Psychiatry
J KohlerB Volk
© 2021 Meta ULC. All rights reserved