Diagnosis and treatment of fungal infections in patients with hematologic malignancies

Hematological Oncology
F RadaelliR Mozzana

Abstract

A diagnosis of deep-seated mycosis was made in 54 patients with hematologic malignancies, severe neutropenia and fever, based on a set of clinical and laboratory criteria. Standardized antifungal treatment was started in 31 patients who seven days after onset of fever had not responded to antibiotics; the fungal infection was cured in 13, all of whom had a simultaneous remission of neutropenia, whereas the other 18 who did not respond to antifungal treatment, all had a falling or static neutrophil count. None of the 23 patients who were given no or inadequate antifungal treatment survived regardless of the neutrophil count and/or phase of the hematologic disease. We discuss the suitability of utilizing empirical criteria for a diagnosis of disseminated fungal infection as a basis for starting antifungal therapy in this type of patient.

References

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Mar 1, 1970·Medicine·R C YoungV T DeVita
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Jun 1, 1981·Annals of Internal Medicine·R P GaleJ Zighelboim

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Citations

Aug 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T J Walsh, A Pizzo
Jan 1, 1990·Clinical and Laboratory Haematology·C M OwensA C Newland

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