Abstract
A 7-year-old spayed female domestic shorthair cat was presented for persistent anemia of unknown origin. Splenomegaly was diagnosed through physical examination and abdominal radiographs, and an abdominal ultrasound was performed. The ultrasound showed splenomegaly, as well as one discrete mass in the body of the spleen. A splenectomy was performed and histopathology along with immunohistochemistry for CD18 and CD204 confirmed a diagnosis of hemophagocytic histiocytic sarcoma (HS). Two courses of lomustine (CCNU) chemotherapy were used in this cat along with adjuvant oral prednisolone and iron dextran injections, but the cat eventually succumbed to hepatic failure, presumed to be secondary to metastatic disease. The clinical pathology results and ultrasonographic studies performed before and after treatment in this cat provide useful preliminary information about the biologic behavior and response to treatment for this rare cancer. This is also the first reported case where both CD18 and CD204 were strongly positive, confirming hemophagocytic HS in a cat.
References
Jul 10, 2002·Veterinary Pathology·V K Affolter, P F Moore
Jan 1, 1997·Veterinary Clinical Pathology·R. M. WaltonM. A. Thrall
Sep 13, 2006·Veterinary Pathology·P F MooreW Vernau
Apr 25, 2007·Journal of Feline Medicine and Surgery·Jennifer L BaezFrances S Shofer
Mar 28, 2008·Veterinary Clinical Pathology·Kristen R Friedrichs, Karen M Young
May 21, 2009·Veterinary and Comparative Oncology·K A SkorupskiM S Kent
Jul 7, 2009·The Journal of Veterinary Medical Science·Kaori IdeHajime Tsujimoto
Jul 2, 2011·Journal of the American Veterinary Medical Association·Shawna L KlahnNikolaos G Dervisis
Jan 13, 2012·Veterinary and Comparative Oncology·C F SabaD H Thamm
May 25, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Abigail L ShearinElaine A Ostrander
Jul 10, 2012·Journal of Feline Medicine and Surgery·Margaret L MusserJohn D Chretin
Aug 21, 2012·Journal of Comparative Pathology·Y KatoH Sakai
Jan 8, 2014·Veterinary Pathology·P F Moore
Jun 26, 2015·Veterinary and Comparative Oncology·S A ColletteK A Skorupski
Dec 17, 2015·The Journal of Veterinary Medical Science·Atigan ThongtharbHiroyuki Nakayama
Jun 24, 2016·Veterinary and Comparative Oncology·N G DervisisL Cesario
Jul 26, 2017·The Journal of Veterinary Medical Science·Mio IshimoriKimimasa Takahashi