Diagnosis and Treatment of Hypopituitarism

Endocrinology and Metabolism
Seong Yeon Kim

Abstract

Hypopituitarism is a chronic endocrine illness that caused by varied etiologies. Clinical manifestations of hypopituitarism are variable, often insidious in onset and dependent on the degree and severity of hormone deficiency. However, it is associated with increased mortality and morbidity. Therefore, early diagnosis and prompt treatment is necessary. Hypopituitarism can be easily diagnosed by measuring basal pituitary and target hormone levels except growth hormone (GH) and adrenocorticotropic hormone (ACTH) deficiency. Dynamic stimulation tests are indicated in equivocal basal hormone levels and GH/ACTH deficiency. Knowledge of the use and limitations of these stimulation tests is mandatory for proper interpretation. It is necessary for physicians to inform their patients that they may require lifetime treatment. Hormone replacement therapy should be individualized according to the specific needs of each patient, taking into account possible interactions. Long-term endocrinological follow-up of hypopituitary patients is important to monitor hormonal replacement regimes and avoid under- or overtreatment.

References

Jun 9, 1994·The New England Journal of Medicine·M L Vance
Mar 1, 1994·Postgraduate Medical Journal·A H Balen, P J Manning
May 7, 1998·Endocrine Reviews·S M ShaletB M Brennan
Sep 27, 2001·Endocrinology and Metabolism Clinics of North America·S BhasinM Javanbakht
May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Gudmundur JohannssonF Anders Karlsson
Jun 6, 2003·Lancet·Wiebke Arlt, Bruno Allolio
May 25, 2004·Expert Opinion on Pharmacotherapy·Jamie C Smith
Mar 2, 2006·Pituitary·M O van Aken, S W J Lamberts
Apr 7, 2006·Postgraduate Medical Journal·V K B Prabhakar, S M Shalet
Nov 2, 2006·Pituitary·Paola Ascoli, Francesco Cavagnini
Apr 18, 2008·Pituitary·Giuseppe ReimondoAlberto Angeli
Jun 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Shalender BhasinUNKNOWN Task Force, Endocrine Society
Mar 23, 2011·Nature Reviews. Endocrinology·Shlomo Melmed
Feb 18, 2012·The Journal of Clinical Endocrinology and Metabolism·Richard I DorinFrank K Urban
May 8, 2013·The Journal of Clinical Endocrinology and Metabolism·Lawrence C Layman

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Citations

Oct 13, 2017·Annals of Pediatric Endocrinology & Metabolism·Kyung Mi Jang, Cheol Woo Ko
Mar 12, 2020·Scandinavian Journal of Immunology·Sukru CekicSara Sebnem Kilic
Dec 9, 2017·The Journal of Clinical Endocrinology and Metabolism·Eugenie A HsuChristian L Roth
Jul 24, 2018·F1000Research·Abbas Ali MansourIbrahim Hani Hussein
Dec 14, 2018·Frontiers in Endocrinology·Maria de Fátima de Magalhães GonzagaLuiz Augusto Casulari
Feb 26, 2020·Case Reports in Neurological Medicine·Maria das Dores Medina-Lopes, Luiz Augusto Casulari
Aug 9, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Tugce ApaydinPinar Kadioglu
Oct 13, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Guy I SydneyStavroula A Paschou
Sep 4, 2020·Seminars in Respiratory and Critical Care Medicine·Gennaro MartucciKarin Amrein
Jan 29, 2021·Canadian Journal of Gastroenterology & Hepatology·Ana-Maria SingeapAnca Trifan
Mar 4, 2021·Journal of the Endocrine Society·Jonathan LeeJose M Garcia
Apr 22, 2021·Sudanese Journal of Paediatrics·Samar S HassanMohamed A Abdullah
Jul 25, 2021·Biochimica Et Biophysica Acta. Proteins and Proteomics·Arghya BanerjeeSanjeeva Srivastava

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Methods Mentioned

BETA
hormone replacement treatment
hormone replacement therapy

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