Diagnosis and treatment of recurrent high-grade astrocytoma

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Nicholas A ButowskiSusan M Chang

Abstract

High-grade gliomas represent a significant source of cancer-related death, and usually recur despite treatment. In this analysis of current brain tumor medicine, we review diagnosis, standard treatment, and emerging therapies for recurrent astrocytomas. Difficulties in interpreting radiographic evidence, especially with regard to differentiating between tumor and necrosis, present a formidable challenge. The most accurate diagnoses come from tissue confirmation of recurrent tumor, but a combination of imaging techniques, such as magnetic resonance spectroscopy imaging, may also be relevant for diagnosis. Repeat resection can prolong life, but repeat irradiation of the brain poses serious risks and results in necrosis of healthy brain tissue; therefore, reirradiation is usually not offered to patients with recurrent tumors. We describe the use of conventional radiotherapy, intensity-modulated radiotherapy, brachytherapy, radiosurgery, and photodynamic therapy for recurrent high-grade glioma. The use of chemotherapy is limited by drug distribution and toxicity, but the development of new drug-delivery techniques such as convection-enhanced delivery, which delivers therapeutic molecules at an effective concentration directly to th...Continue Reading

References

Jan 15, 1993·International Journal of Radiation Oncology, Biology, Physics·W Y GuoL Steiner
Sep 1, 1996·International Journal of Radiation Oncology, Biology, Physics·G S BaumanD A Larson
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·S F ShepherdM Brada
May 1, 1997·Seminars in Surgical Oncology·P K SneedP H Gutin
Nov 11, 1998·General Pharmacology·A Gescher
Feb 25, 1999·International Journal of Radiation Oncology, Biology, Physics·R S HudesW J Curran
Apr 7, 1999·International Journal of Radiation Oncology, Biology, Physics·L E GasparD A Yakar
Apr 28, 1999·Journal of Neuropathology and Experimental Neurology·K H Plate
Aug 24, 1999·Pharmacology & Therapeutics·P J Parker
Dec 29, 1999·International Journal of Radiation Oncology, Biology, Physics·K H ChoH B Clark
Jan 19, 2000·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·J SchlaierA Brawanski
Feb 9, 2000·Investigational New Drugs·W D Jarvis, S Grant
Feb 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A FineW K Yung
Nov 1, 2000·Cell·T Schmelzle, M N Hall
Apr 28, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·T VeningaR W van der Maazen
Jan 12, 2002·Zentralblatt für Neurochirurgie·M Pinsker, C Lumenta
Dec 7, 2002·International Journal of Clinical Pharmacology and Therapeutics·B Kaina, M Christmann
Dec 13, 2002·American Journal of Clinical Oncology·George VoynovRobert Dowsett
Apr 12, 2003·Neuroimaging Clinics of North America·Terence Z WongR Edward Coleman
Nov 1, 2003·Cancer Chemotherapy and Pharmacology·Kristan A KeyesBeverly A Teicher
Nov 26, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeremy N RichHenry S Friedman
Dec 12, 2003·Cancer·Peter HauAndreas Steinbrecher
Apr 15, 2004·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Mark A RosenthalLawrence Cher
Aug 5, 2004·Investigational New Drugs·Susan M ChangUNKNOWN North American Brain Tumor Consortium And The National Cancer Institute
Aug 12, 2004·British Journal of Cancer·E FranceschiL Crinò
Oct 19, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·S SinhaI R Whittle
Nov 6, 2004·Journal of Neuro-oncology·E Antonio ChioccaMartine L M Lamfers
Dec 16, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A WeltU Vanhoefer
Jan 1, 2005·Topics in Magnetic Resonance Imaging : TMRI·Soonmee Cha

❮ Previous
Next ❯

Citations

Feb 13, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yuichi TangeTadanori Tomita
Sep 13, 2008·Journal of Neuro-oncology·Jaishri O BlakeleyUNKNOWN New Approaches to Brain Tumor Therapy (NABTT) Consortium
Aug 21, 2012·Current Treatment Options in Oncology·Laura K AguilarE Antonio Chiocca
Sep 16, 2010·Current Treatment Options in Neurology·Eudocia C QuantAndrew D Norden
Apr 16, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Leoncio Arribas AlpuenteRicardo Yayá Tur
Apr 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Andrej BesseOndrej Slaby
May 29, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Haijun ZhangJennifer L Knauss
Aug 20, 2008·Nature Clinical Practice. Oncology·A Gregory SorensenRakesh K Jain
Aug 2, 2008·The New England Journal of Medicine·Patrick Y Wen, Santosh Kesari
Nov 24, 2006·The Neurologist·Andrew D Norden, Patrick Y Wen
Apr 5, 2007·Paediatric Drugs·Iacopo SardiMaura Massimino
Mar 31, 2009·Journal of Neurosurgery·Jason SheehanShaojie Han
Nov 18, 2011·ISRN Oncology·Annamaria Cimini, Rodolfo Ippoliti
Aug 22, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yingqun Tao, Guobiao Liang
Oct 15, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Benping ZhangWeizhi Wang
May 23, 2013·Pharmacology & Therapeutics·Tareq A JuratliDietmar Krex
Apr 7, 2012·Journal of Cancer Research and Clinical Oncology·Francisco das Chagas Abreu da SilveiraLidia Maria da Fonte de Amorim
Apr 3, 2008·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Lauren VanderSpekDavid Macdonald
Jul 9, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jinyang MaHuojun Hu
Dec 13, 2012·Acta Oncologica·Lihong ShiBaogang Zhang
Jun 4, 2008·Upsala Journal of Medical Sciences·Fredrik Johansson Swartling
Feb 26, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Florentin SpäthBeatrice Melin
Jul 4, 2012·Neurosurgery Clinics of North America·Jacob RuzevickMichael Lim
May 7, 2015·Pharmacology & Therapeutics·Constantinos Alifieris, Dimitrios T Trafalis
Jan 7, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bin DaiLiwei Zhang
Jun 18, 2010·European Journal of Radiology·K PinkerT H Helbich
May 18, 2010·International Journal of Radiation Oncology, Biology, Physics·Jarrod B AdkisonSteven P Howard
Nov 27, 2007·International Journal of Radiation Oncology, Biology, Physics·Ramona Mayer, Peter Sminia
Oct 30, 2007·Neurologic Clinics·Sith SathornsumeteeDavid A Reardon
Nov 8, 2008·Annals of the New York Academy of Sciences·Sith Sathornsumetee, Jeremy N Rich

❮ Previous
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