Diagnosis of acquired bone marrow failure syndrome during childhood using the 2008 World Health Organization classification system.

International Journal of Hematology
Wen-Yu YangXiao-Fan Zhu

Abstract

Distinguishing hypoplastic myelodysplastic syndrome from aplastic anemia (AA) is challenging. In the present study, Japanese and Chinese pediatric hematologists and pathologists conducted a joint review of bone marrow (BM) smears and trephine biopsies in 100 children with acquired BM failure syndrome, using the criteria proposed in the 2008 edition of the World Health Organization classification of hematopoietic and lymphoid tissues. The final consensus for the diagnoses of 100 children was AA in 29 patients, refractory cytopenia of childhood (RCC) in 58 patients, and refractory cytopenia with multilineage dysplasia (RCMD) in 13 patients. No significant differences between Japanese and Chinese children were found with regards to clinical and laboratory findings, or the distribution of diagnoses. Patients with RCC/RCMD showed milder disease severity and BM hypocellularity than those with AA. To establish the provisional entities for RCC, it is essential to prospectively compare the clinical outcomes between AA and RCC groups in a large number of patients.

Citations

Nov 26, 2013·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Ahmad KhosraviAkbar Fotouhi
Mar 8, 2017·Expert Review of Hematology·Seiji Kojima
Jul 2, 2018·Current Oncology Reports·Nao Yoshida, Seiji Kojima
May 24, 2020·Bone Marrow Transplantation·Nao YoshidaUNKNOWN Pediatric Aplastic Anemia Working Group of the Japan Society for Hematopoietic Cell Transplantation

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Lancet
Carlene M M LawesInternational Society of Hypertension
American Journal of Respiratory and Critical Care Medicine
Jørgen VestboRoberto Rodriguez-Roisin
Global Health Action
Zunaid Ahsan KararPeter Kim Streatfield
© 2021 Meta ULC. All rights reserved