Diagnosis of asthma - a new approach

Allergy
O Löwhagen

Abstract

Current definition of asthma involves four cornerstones: inflammation, hyperresponsiveness, bronchoconstriction, and symptoms. In research, the symptoms have had the slightest attention. According to international guidelines, the asthma symptoms are episodic breathlessness, wheeze, cough, tightness of the chest, and shortness of breath. As there are several symptoms, a primary question is how they are related to bronchoconstriction, the main clinical feature of asthma. Symptoms and lung function tests are regularly used for the evaluation of clinical health status and effect of treatment. However, there is no or poor correlation between these two variables, which means that they represent different mechanisms. Reduced lung function, such as a low FEV(1) , represents bronchial constriction, what do the symptoms represent? Some symptoms such as breathlessness and shortness of breath seem not to be evidence-based asthma symptoms. Focusing on bronchial obstruction is important in view of the potential risk of asthma attacks, but nonobstructive symptoms occur frequently and may also cause severe discomfort and poor quality of life. Interpreting all symptoms as signs of bronchoconstriction (asthma) may lead to misinterpretation when ...Continue Reading

References

Jun 1, 1992·The American Review of Respiratory Disease·O TaguchiT Takishima
Dec 1, 1991·Journal of Applied Physiology·O TaguchiT Takishima
Nov 1, 1990·The American Review of Respiratory Disease·P M SimonS E Weinberger
Apr 1, 1989·Respiration Physiology·R B BanzettR Brown
Oct 1, 1989·The American Review of Respiratory Disease·P M SimonS E Weinberger
May 1, 1989·The American Review of Respiratory Disease·R M SchwartzsteinS E Weinberger
Jan 1, 1984·Journal of Psychosomatic Research·P Grossman, J C de Swart
Apr 1, 1981·Clinical Science·S C GandeviaE J Campbell
Dec 7, 1995·The New England Journal of Medicine·H L Manning, R M Schwartzstein
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·D M LougheedD E O'Donnell
Sep 1, 1993·The Journal of Allergy and Clinical Immunology·D Cypcar, W W Busse
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·A B Kay
Nov 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S R NimmagaddaS J Szefler
Jan 1, 1997·The Netherlands Journal of Medicine·H Hornsveld, B Garssen
May 1, 1997·Journal of Psychosomatic Research·C Bass
Jan 1, 1997·Scandinavian Journal of Caring Sciences·K C RingsbergI Akerlind
Oct 12, 1999·Respiration; International Review of Thoracic Diseases·K TetzlaffB Dahme
Nov 26, 1999·The European Respiratory Journal·J Pekkanen, N Pearce
Dec 3, 1999·Respiratory Medicine·O LöwhagenN Jörgensen
Feb 1, 2000·Respiratory Medicine·O Löwhagen
Jun 8, 2000·Annals of the New York Academy of Sciences·N Barzilai, G Gupta
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·M L MoyR M Schwartzstein
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·K J KillianP M O'Byrne
Jan 12, 2001·The European Respiratory Journal·K F RabeW C Maier
May 5, 2001·BMJ : British Medical Journal·D Keeley, L Osman
May 22, 2001·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·K R ChapmanS Zimmerman
Aug 21, 2001·The European Respiratory Journal·P Bergquist, G K Crompton
Oct 20, 2001·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·H L Manning, R M Schwartzstein
Nov 1, 2001·Respiratory Research·B J Undem, M J Carr
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·Andrew P BinksRichard M Schwartzstein
Mar 15, 2002·Current Allergy and Asthma Reports·Bradley J Undem, Michael J Carr
Sep 24, 2002·Respiratory Medicine·A JohanssonM Bende
Nov 27, 2002·Journal of Occupational and Environmental Medicine·Ewa Ternesten-HasséusEva Millqvist
Mar 17, 2004·International Archives of Occupational and Environmental Health·Steven NordinMats Bende
May 14, 2004·Current Opinion in Pharmacology·Ian M Adcock, Kazuhiro Ito
Jul 9, 2004·The Journal of Allergy and Clinical Immunology·Klaus F RabeScott T Weiss
Feb 3, 2005·The European Respiratory Journal·G ScanoM Grazzini
Apr 26, 2005·American Journal of Respiratory and Critical Care Medicine·Sally Wenzel

❮ Previous
Next ❯

Citations

Oct 16, 2013·Current Opinion in Infectious Diseases·Jason Trubiano, Elizabeth Phillips
Sep 5, 2013·Southern Medical Journal·Gregory Robert DionKevin C McMains
Jan 1, 2014·Current Opinion in Rheumatology·Kenneth F Baker, John D Isaacs
Feb 19, 2014·Current Opinion in Allergy and Clinical Immunology·Fulvio BraidoRuby Pawankar
Feb 19, 2014·Current Opinion in Allergy and Clinical Immunology·Carlos E Baena-Cagnani, R Maximiliano Gómez
Jul 6, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Lan JiangLi Zuo
Aug 19, 2014·Complementary Therapies in Clinical Practice·O Löwhagen, Per Bergqvist
Dec 6, 2014·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Olle Löwhagen
Dec 12, 2012·Anaesthesia·K Somasundaram, J Ball
Feb 11, 2014·Asian Pacific Journal of Tropical Medicine·Amanda Sánchez-RecillasSamuel Estrada-Soto
May 26, 2017·PloS One·Lucia CalcianoSimone Accordini
Sep 15, 2017·Current Medical Research and Opinion·Daniel ColodencoChristian Domingo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.