Diagnosis of bronchiectasis and airway wall thickening in children with cystic fibrosis: Objective airway-artery quantification

European Radiology
Wieying KuoHarm A W M Tiddens

Abstract

To quantify airway and artery (AA)-dimensions in cystic fibrosis (CF) and control patients for objective CT diagnosis of bronchiectasis and airway wall thickness (AWT). Spirometer-guided inspiratory and expiratory CTs of 11 CF and 12 control patients were collected retrospectively. Airway pathways were annotated semi-automatically to reconstruct three-dimensional bronchial trees. All visible AA-pairs were measured perpendicular to the airway axis. Inner, outer and AWT (outer-inner) diameter were divided by the adjacent artery diameter to compute AinA-, AoutA- and AWTA-ratios. AA-ratios were predicted using mixed-effects models including disease status, lung volume, gender, height and age as covariates. Demographics did not differ significantly between cohorts. Mean AA-pairs CF: 299 inspiratory; 82 expiratory. 131 inspiratory; 58 expiratory. All ratios were significantly larger in inspiratory compared to expiratory CTs for both groups (p<0.001). AoutA- and AWTA-ratios were larger in CF than in controls, independent of lung volume (p<0.01). Difference of AoutA- and AWTA-ratios between patients with CF and controls increased significantly for every following airway generation (p<0.001). Diagnosis of bronchiectasis is highly depend...Continue Reading

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Citations

Mar 2, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Harm A W M TiddensPierluigi Ciet
Jul 16, 2019·Medical Physics·Raghavendra SelvanMarleen de Bruijne
Feb 7, 2020·European Radiology·Wieying KuoUNKNOWN Normal Chest CT study group
Sep 24, 2020·ERJ Open Research·Valentina FerraroMarielle W H Pijnenburg
Jun 20, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Harm A W M TiddensPierluigi Ciet
Jun 28, 2020·Pediatric Pulmonology·Jennifer L GoralskiJason C Woods
Jan 21, 2021·Bioengineering·Lumei LiuTendy Chiang
Apr 13, 2021·Expert Review of Respiratory Medicine·Pedro Mondéjar-LópezÒscar Asensio de la Cruz
Jul 15, 2021·Seminars in Respiratory and Critical Care Medicine·Francesco AmatiStefano Aliberti
Jul 30, 2021·ERJ Open Research·Michael Fayon, Fabien Beaufils
Aug 13, 2021·BJR Open·Roberta Eufrasia LeddaGianluca Milanese
Sep 6, 2021·Current Opinion in Pulmonary Medicine·Claire CrowleyMichael M Maher
Nov 30, 2021·European Radiology Experimental·Ivan DudurychMarleen de Bruijne

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