Diagnosis of Cryptosporidium parvum in patients with severe diarrhea and AIDS

Digestive Diseases and Sciences
P D GreenbergJ P Cello

Abstract

The sensitivity of noninvasive stool microscopy and endoscopic biopsies from the upper and lower gastrointestinal tract in the diagnosis of Cryptosporidium parvum in patients with AIDS is not known. We evaluated 30 severely immunocompromised patients with AIDS and diarrhea caused by C. parvum. C. parvum was diagnosed by either stool microscopy, endoscopic biopsy, or both. Patients submitted a mean (+/-SEM) of 3.3 +/- 0.3 stool samples, each microscopically evaluated for ova and parasites. Upper and lower endoscopy were performed in all patients and endoscopic biopsies were taken throughout the gastrointestinal tract. Diarrhea had been present for a mean of 13.5 +/- 2.3 months and mean daily stool weight was 1224 +/- 127 g. Overall, individual stool samples were insensitive, as only 53% demonstrated C. parvum. When multiple stool samples were considered for each patient, 73% of subjects demonstrated C. parvum in at least one stool sample. The sensitivity of endoscopy with mucosal biopsy varied by anatomical location: stomach (11%), duodenum (53%), terminal ileum (91%), and colon (60%). The terminal ileum was significantly more likely than the duodenum to demonstrate C. parvum (P = 0.03). Thus, duodenal biopsies are much less sen...Continue Reading

References

Nov 1, 1990·Annals of Internal Medicine·T S Kotler, G A Diamond
Sep 15, 1990·Annals of Internal Medicine·D P KotlerJ M Orenstein
Dec 25, 1986·The New England Journal of Medicine·L Jokipii, A M Jokipii
Jul 1, 1983·Journal of Clinical Microbiology·L S GarciaR Y Shimizu

❮ Previous
Next ❯

Citations

Sep 12, 2000·Current Gastroenterology Reports·C M Noyer, L J Brandt
Apr 4, 2002·Alimentary Pharmacology & Therapeutics·C L ChenR J Mack
Oct 13, 2006·Current Opinion in Gastroenterology·C D Huston, W A Petri
Mar 10, 2001·Arquivos De Gastroenterologia·C M ClementeM A Rodrigues
Jul 15, 1997·Hospital Practice·A T Marshall, J T LaMont
Apr 6, 2004·Gastrointestinal Endoscopy Clinics of North America·John P Cello
Aug 2, 2006·Gastroenterology Clinics of North America·David B Huang, A Clinton White

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.