Diagnosis of Cushing's Syndrome in the Modern Era

Endocrinology and Metabolism Clinics of North America
Lynnette Kaye Nieman

Abstract

Four challenges complicate the evaluation for Cushing syndrome. These challenges include increasing global prevalence of obesity and diabetes; increasing use of exogenous glucocorticoids, which cause a Cushing syndrome phenotype; the confusion caused by nonpathologic hypercortisolism not associated with Cushing syndrome, which may present with symptoms consistent with Cushing syndrome; and difficulty identifying pathologic hypercortisolism when it is extremely mild or cyclic or in renal failure, incidental adrenal masses, and pregnancy. Careful choice of screening tests, consideration of confounding conditions, and repeated testing when the results are ambiguous improve the accuracy of diagnosis.

Citations

Mar 5, 2020·The New England Journal of Medicine·Shlomo Melmed
Dec 12, 2019·Current Treatment Options in Cardiovascular Medicine·Jamie S Hirsch, Susana Hong
Dec 4, 2019·Wiener klinische Wochenschrift·Thomas WeberUNKNOWN Österreichische Gesellschaft für Kinder- und Jugendheilkunde
Feb 16, 2021·Frontiers in Endocrinology·Barbara StachowskaMarek Bolanowski
Mar 2, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Chang Ho AhnMan Ho Choi
Mar 3, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Arza RossetKaren Tordjman
May 11, 2021·Frontiers in Endocrinology·Renata Świątkowska-StodulskaKrzysztof Sworczak

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