Diagnosis of epithelial ovarian cancer using a combined protein biomarker panel.

British Journal of Cancer
Matthew R RussellRobert L J Graham

Abstract

An early detection tool for EOC was constructed from analysis of biomarker expression data from serum collected during the UKCTOCS. This study included 49 EOC cases (19 Type I and 30 Type II) and 31 controls, representing 482 serial samples spanning seven years pre-diagnosis. A logit model was trained by analysis of dysregulation of expression data of four putative biomarkers, (CA125, phosphatidylcholine-sterol acyltransferase, vitamin K-dependent protein Z and C-reactive protein); by scoring the specificity associated with dysregulation from the baseline expression for each individual. The model is discriminatory, passes k-fold and leave-one-out cross-validations and was further validated in a Type I EOC set. Samples were analysed as a simulated annual screening programme, the algorithm diagnosed cases with >30% PPV 1-2 years pre-diagnosis. For Type II cases (~80% were HGS) the algorithm classified 64% at 1 year and 28% at 2 years tDx as severe. The panel has the potential to diagnose EOC one-two years earlier than current diagnosis. This analysis provides a tangible worked example demonstrating the potential for development as a screening tool and scrutiny of its properties. Limits on interpretation imposed by the number of s...Continue Reading

References

Apr 28, 2004·The American Journal of Pathology·Ie-Ming Shih, Robert J Kurman
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew BerchuckJeffrey R Marks
Jul 25, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H KobayashiT Kitanaka
Mar 5, 2011·Cancer Prevention Research·Claire S ZhuUNKNOWN PLCO Project Team
Mar 19, 2011·BMC Bioinformatics·Xavier RobinMarkus Müller
Apr 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean-Pierre GilletMichael M Gottesman
May 11, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Steven J Skates
May 3, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M LudovisiD Jurkovic
Jan 28, 2016·International Journal of Cancer. Journal International Du Cancer·Matthew R RussellRobert L J Graham
Mar 26, 2016·The American Journal of Pathology·Robert J Kurman, Ie-Ming Shih
May 21, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Archana R SimmonsSteven J Skates
Jun 1, 2016·Frontiers in Oncology·Michael W Kattan
Aug 26, 2016·Nature Reviews. Disease Primers
Feb 28, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adam N RosenthalUNKNOWN United Kingdom Familial Ovarian Cancer Screening Study collaborators
Apr 14, 2017·Diagnostics·Edward J Pavlik

❮ Previous
Next ❯

Citations

Dec 17, 2020·Cancers·Parsa CharkhchiMohammad R Akbari
Mar 7, 2021·Journal of Personalized Medicine·Christen A KhellaMichael L Gatza
Oct 15, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Robert C BastSteven J Skates
Aug 23, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Louise FaaborgKarina Dahl Steffensen

❮ Previous
Next ❯

Clinical Trials Mentioned

ISRCTN22488978
NCT00058032

Software Mentioned

pROC
riverplot
R
UKCTOCS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Juan Luis AlcázarMatías Jurado
Oncology Letters
Xiao-Ying Zhang, Pei-Ying Zhang
© 2021 Meta ULC. All rights reserved