Diagnosis of extraesophageal reflux in children with chronic otitis media with effusion using Peptest

International Journal of Pediatric Otorhinolaryngology
Martin FormánekPetr Matoušek

Abstract

The aim of the study was to investigate whether Peptest, an immunoassay used to detect pepsin, could be used to diagnose extraesophageal reflux (EER) in children with chronic otitis media with effusion (OME). The results obtained using this fast, simple and non-expensive method were compared with the results of previous studies. Children 1-7 years old who had been diagnosed with OME and who were undergoing myringotomy with insertion of a ventilation tube were included in the prospective study. Middle ear fluid obtained during myringotomy was analyzed with Peptest to determine the presence of pepsin, and hence EER. Bilateral and unilateral myringotomy was performed in 15/44 (34.1%) and 29/44 (65.9%) children, respectively. Pepsin in the middle ear was detected in 14/44 (31.8%) children and in 19/59 (32.2%) middle ear specimens. Serous and mucous samples were positive for pepsin in 11/32 (34.4%) and 6/27 (22.2%) cases, respectively. Pepsin in the middle ear was detected in 3/7 children (42.9%) with bronchial asthma (p=0.662). Pepsin was detected in 1/3 of middle ear specimens of patients with OME. These patients probably suffer from more severe reflux and therefore would be potential candidates for antireflux therapy. However, th...Continue Reading

References

Jan 1, 1994·International Journal of Pediatric Otorhinolaryngology·W S Gibson, W Cochran
Sep 14, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S B HeavnerH C Pillsbury
Feb 21, 2002·Lancet·Andrea TaskerJeffery P Pearson
Apr 20, 2002·Journal of Pediatric Gastroenterology and Nutrition·Vojko RozmanicMarko Velepic
Oct 23, 2002·The Annals of Otology, Rhinology, and Laryngology·Johan PoelmansLouw Feenstra
Mar 17, 2005·Acta Oto-laryngologica·Bahar KeleşBedri Ozer
Aug 2, 2005·Journal of Pediatric Gastroenterology and Nutrition·Linda DealJoseph F Fitzgerald
Sep 7, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Judith E C LieuRavindra Uppaluri
Apr 10, 2007·The Laryngoscope·Nikki JohnstonJamie A Koufman
Jun 23, 2007·The Laryngoscope·Matthew CrapkoNikki Johnston
Jul 18, 2008·The Laryngoscope·Robert C O'ReillyDevendra I Mehta
Oct 23, 2008·Current Allergy and Asthma Reports·Zhaoping HeDevendra Mehta
Apr 6, 2011·Journal of Pediatric Gastroenterology and Nutrition·Leah KleinmanOmar Dabbous

❮ Previous
Next ❯

Citations

Sep 29, 2015·Expert Review of Gastroenterology & Hepatology·Yvan Vandenplas, Bruno Hauser
Nov 21, 2015·International Journal of Pediatric Otorhinolaryngology·Giannicola IannellaGiuseppe Magliulo
May 13, 2017·Brain & Development·Naoki HashizumeYushiro Yamashita
Apr 13, 2019·Alimentary Pharmacology & Therapeutics·Caroline RaceStuart A Riley
Dec 15, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jing WangYang Xu
Apr 15, 2021·Journal of Voice : Official Journal of the Voice Foundation·Miguel Mayo-YáñezLucía González-Torres
Mar 13, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jerome R LechienSven Saussez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Otolaryngologia polska. The Polish otolaryngology
Mohammed A GomaaYaser Makram Elsherbeny
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
C B ShawR W Farr
International Journal of Pediatric Otorhinolaryngology
Riccardo D'ereditá, Udayan K Shah
© 2022 Meta ULC. All rights reserved