PMID: 2503669Jan 1, 1989Paper

Diagnosis of gastric cancers with fluorescein-labeled monoclonal antibodies to carcinoembryonic antigen

Lasers in Surgery and Medicine
M TatsutaK Kikuchi

Abstract

Forty gastric adenocarcinomas in 30 resected stomachs were examined by an endoscopic immunofluorescent technique using fluorescein isothiocyanate (FITC)-labeled antibodies to carcinoembryonic antigen (CEA). Fluorescence images of the tumors were obtained with a newly developed endoscopic television system for detecting faint fluorescence. Computer-assisted processing was used to enhance the detection and localization of the tumors visualized by the immunofluorescent technique. Twenty seven (90%) of 30 tumors showed positive fluorescence after treatment with FITC-labeled antibodies for 60 minutes, whereas only two (40%) of five cancers could be detected by the immunofluorescent technique after treatment with antibodies for less than 60 minutes. There was no significant relationship between positive fluorescence and the gross and histological types or the stages of the tumors. In contrast, no positive fluorescence could be demonstrated in cases of benign gastric lesions or after pretreatment with FITC-labeled alpha-fetoprotein. This study therefore suggests that the immunofluorescent technique using FITC-labeled anti-CEA antibodies can be useful in detecting the early stages of gastric cancer.

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Citations

Jul 3, 2003·Bioorganic & Medicinal Chemistry·Masaya TadatsuHiromi Taue
May 16, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·K InayamaK Takesako
Apr 4, 2008·Nature·Ralph Weissleder, Mikael J Pittet
May 10, 2002·Journal of Gastroenterology and Hepatology·Ralph S DacostaNorman E Marcon
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S FolliJ C Givel
Jun 1, 2004·Inflammatory Bowel Diseases·E Dekker, P Fockens
Nov 10, 2005·Gastrointestinal Endoscopy Clinics of North America·Evelien Dekker, Paul Fockens
Sep 1, 2006·Photodiagnosis and Photodynamic Therapy·Hiromi YanoHiroshi Kido
Oct 15, 2013·Advanced Drug Delivery Reviews·Numfon KhemthongcharoenWibool Piyawattanametha
Mar 16, 2006·The Journal of Medical Investigation : JMI·Yoko TadatsuYoshimitsu Nagao
Jul 9, 2005·European Journal of Gastroenterology & Hepatology·Evelien Dekker, Paul Fockens

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