Diagnosis of Heart Failure With Preserved Ejection Fraction: Machine Learning of Spatiotemporal Variations in Left Ventricular Deformation

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Mahdi TabassianJan D'hooge

Abstract

Stress testing helps diagnose heart failure with preserved ejection fraction (HFpEF), but there are no established criteria for quantifying left ventricular (LV) functional reserve. The aim of this study was to investigate whether comprehensive analysis of the timing and amplitude of LV long-axis myocardial motion and deformation throughout the cardiac cycle during rest and stress can provide more informative criteria than standard measurements. Velocity, strain, and strain rate traces were measured from all 18 LV segments by echocardiographic myocardial velocity imaging at rest and during semisupine bicycle exercise in 100 subjects aged 69 ± 7 years, including patients with HFpEF and healthy, hypertensive, and breathless control subjects. A machine-learning algorithm, composed of an unsupervised statistical method and a supervised classifier, was used to model spatiotemporal patterns of the traces and compare the predicted labels with the clinical diagnoses. The learned strain rate parameters gave the highest accuracy for allocating subjects into the four groups (overall, 57%; for patients with HFpEF, 81%), and into two classes (asymptomatic vs symptomatic; area under the curve, 0.89; accuracy, 85%; sensitivity, 86%; specifici...Continue Reading

Citations

Feb 18, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Susan StienenPatrick Rossignol
May 16, 2019·Current Treatment Options in Cardiovascular Medicine·Karthik SeetharamPartho P Sengupta
Aug 11, 2019·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·K R SiegersmaJ W Verjans
Feb 11, 2020·Frontiers in Cardiovascular Medicine·Carlos Martin-IslaKarim Lekadir
Jul 2, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Kenya KusunoseMasataka Sata
Jul 1, 2020·Echocardiography·Karthik SeetharamChristopher M Bianco
Jan 31, 2020·Frontiers in Cardiovascular Medicine·Nicolas DuchateauMathieu De Craene
Aug 13, 2020·Current Heart Failure Reports·Jan D LanzerJulio Saez-Rodriguez
Jul 18, 2020·Cardiology Research and Practice·Silvia RomitiErnesto Greco
May 20, 2019·JACC. Cardiovascular Imaging·Kenya KusunoseMasataka Sata
Jan 12, 2021·Frontiers in Cardiovascular Medicine·Karthik SeetharamPartho P Sengupta
Oct 17, 2020·Current Opinion in Cardiology·Sagar RankaAmit Noheria
Apr 2, 2021·Circulation Research·Sandosh PadmanabhanAnna F Dominiczak
Jul 11, 2021·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Filip LoncaricBart Bijnens
Oct 13, 2021·Journal of Pharmacokinetics and Pharmacodynamics·Limei ChengGuo-Wei Wei

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