PMID: 15230669Jul 3, 2004Paper

Diagnosis of Helicobacter pylori infection in patients with bleeding ulcer disease: rapid urease test and histology

Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
M Castro-FernándezJ Vargas-Romero

Abstract

The endoscopic diagnosis of Helicobacter pylori infection in patients with bleeding peptic ulcer is limited by a decreased sensitivity in standard invasive tests, rapid urease test and histology. There is controversy about the convenience of using one, neither, or both diagnostic tests. To evaluate the results of simultaneously performed rapid urease test and histology in the diagnosis of Helicobacter pylori infection (H. pylori) in patients with bleeding peptic ulcer. We included 173 patients, 98 male and 75 female, with an average age of 62 years (18-88), with upper gastrointestinal bleeding secondary to duodenal ulcer (115) or gastric ulcer (58), diagnosed within 24 hours after hospital admission. None of the patients had received treatment for H. pylori, proton pump inhibitors or antibiotics in the two weeks prior to the upper gastrointestinal bleeding episode. H. pylori infection was investigated in all patients by two antral biopsy samples for histological study (hematoxilin-eosin) and one or two antral biopsies for rapid urease test (Jatrox-H.p.-test). In cases with a negative urease test and histology, a 13C urea breath test was performed. Infection was considered present when at least one invasive test or the breath te...Continue Reading

Associated Clinical Trials

Citations

Jun 1, 2011·PloS One·María José Ramírez-LázaroXavier Calvet
Nov 7, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·B H ChoeK S Lee
Dec 21, 2002·The American Journal of Gastroenterology·Mihnea V ChioreanL Joseph Melton
Mar 26, 2009·Clinical Biochemistry·Rodrigo AlonsoPedro Mata
Mar 19, 2008·Best Practice & Research. Clinical Gastroenterology·M E van Leerdam
Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy

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