Diagnosis of hemochromatosis probands in a community hospital

The American Journal of Medicine
James C BartonT J Alford

Abstract

To evaluate factors that lead to the diagnosis of hemochromatosis probands in a community hospital, including education of physicians about hemochromatosis and iron overload, specialty of physicians, diagnostic indicators of hemochromatosis, and clinical manifestations of hemochromatosis probands. We conducted a hemochromatosis education program for health care personnel associated with a community hospital and the public during 1990 to 1994. Data on physicians who diagnosed probands, diagnostic indicators of hemochromatosis, and manifestations of hemochromatosis and associated illnesses were tabulated. Iron grades of all hospital liver biopsy specimens obtained from Caucasian subjects during 1990 to 1994 were also analyzed. We identified 162 hemochromatosis probands; 66.7% were diagnosed by physicians who participated in our education program. Primary care and internal medicine subspecialty physicians diagnosed 66.7% and 29.6% of probands, respectively, based on elevated serum iron parameters and hepatic enzyme concentrations (51.9% and 36.4% of probands, respectively). Iron overload occurred in 90.7%, and was associated with clinical manifestations in most. Of 844 hospital liver biopsy specimens from Caucasians, 8.5% had incr...Continue Reading

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Citations

Jul 25, 2008·Thyroid : Official Journal of the American Thyroid Association·James C BartonUNKNOWN Hemochromatosis and Iron Overload Screening Study Research Investigators
Sep 12, 2000·Current Gastroenterology Reports·J C Barton, R T Acton
Oct 24, 2007·Genetic Testing·James C BartonUNKNOWN Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators
Jun 23, 1999·Transfusion·J C BartonL F Bertoli
Oct 6, 2000·Journal of Hepatology·P AdamsL W Powell
Oct 28, 2015·Journal of Immunology Research·James C Barton, J Clayborn Barton
Jan 19, 2000·The Journal of Laboratory and Clinical Medicine·J C BartonB E Rothenberg
Aug 21, 2002·Journal of Occupational and Environmental Medicine·James C BartonRonald T Acton
Sep 23, 2003·The American Journal of Gastroenterology·Bret L HickenJames C Barton
Aug 16, 2002·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Ronald T ActonLynya Talley
Mar 24, 2017·Journal of Diabetes Research·James C Barton, Ronald T Acton
Dec 17, 2002·Blood Cells, Molecules & Diseases·James C BartonRonald T Acton
May 5, 2001·Genetics in Medicine : Official Journal of the American College of Medical Genetics·J C BartonR T Acton

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