PMID: 11933270Apr 5, 2002Paper

Diagnosis of histoplasmosis in urine cytology: reactive urothelial changes, a diagnostic pitfall. Case report and literature review of urinary tract infections

Diagnostic Cytopathology
Perkins MukunyadziMargie Scott

Abstract

Histoplasmosis not uncommonly causes systemic infection, particularly in immunocompromised patients. In systemic infection, the urinary tract is often involved, although the diagnosis of histoplasmosis in urine cytologic specimens has never been reported. Urinary tract histoplasmosis may present with gross hematuria, raising clinical suspicion for malignancy. The index case presented with intermittent gross hematuria, suprapubic pain, significant weight loss, hoarse voice, and a painful tongue ulcer. Examination of the patient revealed an ulcerated tongue lesion, an anal ulcer, a polypoid lesion on the vocal cord, and cystoscopic examination of the urinary bladder revealed erythematous patchy areas. Surgical biopsy sections from the vocal cord and tongue lesion were diagnostic of histoplasma infection. Urine cytologic examination showed atypical urothelial cells suspicious for malignancy. However, fungal stains performed on the urine specimen showed histoplasma organisms. We conclude that with a high index of suspicion, and the use of special stains, histoplasma organisms can be identified in urine.

References

Jun 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N R SridharM R First
Mar 1, 1988·The American Journal of Surgical Pathology·A Del MistroK M Simons
Jul 1, 1987·Reviews of Infectious Diseases·M R Bibler, J T Gianis
Jun 1, 1972·The Journal of Urology·W A OrrM P Walzak
Sep 1, 1984·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M C GregoryJ C Argyle
Feb 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A M Robson, R D Craver

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Citations

Jul 4, 2006·Journal of Clinical Pathology·Cheng-Chuan SuChien-Wen Chou
Dec 1, 2008·Surgical Pathology Clinics·Joshua F Coleman, Donna E Hansel
Jan 27, 2018·Journal of the American Animal Hospital Association·Maura Duffy, Alex Gallagher
Feb 3, 2009·Mycopathologia·Alessandro C PasqualottoLuiz Carlos Severo
Apr 5, 2012·Journal of the American Animal Hospital Association·Amanda R TaylorBenjamin D Young
Oct 18, 2003·Current Opinion in Nephrology and Hypertension·Giovanni B Fogazzi, Giuseppe Garigali

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