Diagnosis of Human Echinococcosis via Exhaled Breath Analysis: A Promise for Rapid Diagnosis of Infectious Diseases Caused by Helminths

The Journal of Infectious Diseases
Tesfalem Geremariam WelearegayRadu Ionescu

Abstract

Human echinococcosis is a neglected infectious disease affecting more than 1 million people globally. Its diagnosis is expensive and difficult because of lack of adequate resources in low-resource locations, where most cases occur. A group of volunteers diagnosed with the 2 main types of echinococcosis and corresponding control groups were recruited from hospitals in Tunisia (32 patients with cystic echinococcosis and 43 controls) and Poland (16 patients with alveolar echinococcosis and 8 controls). Breath samples were collected from all patients and analyzed by gas chromatography coupled to mass spectrometry, and a specifically developed electronic nose system. The chemical analysis revealed statistically different concentrations of 2 compounds in the breath of patients with cystic echinococcosis compared to controls, and statistically different concentrations of 7 compounds in the breath of patients with alveolar echinococcosis compared to controls. The discrimination accuracy achieved by the electronic nose system was 100% for cystic echinococcosis and 92.9% for alveolar echinococcosis, while the discrimination accuracy between these 2 patient groups was 92.1%. Here we advocate a noninvasive, fast, easy-to-operate and nonexp...Continue Reading

References

Jan 1, 1991·Free Radical Biology & Medicine·K N Jeejeebhoy
Aug 1, 1994·Free Radical Biology & Medicine·C M KneepkensC C Roy
Jan 1, 1997·Biosensors & Bioelectronics·P WangF Shen
May 10, 2000·Free Radical Biology & Medicine·E Aghdassi, J P Allard
Mar 20, 2003·Emerging Infectious Diseases·Petra KernUNKNOWN European Echinococcosis Registry
Jul 2, 2003·Biosensors & Bioelectronics·Corrado Di NataleArnaldo D'Amico
Jan 17, 2004·Clinical Microbiology Reviews·Johannes Eckert, Peter Deplazes
Mar 26, 2004·Nature Reviews. Microbiology·Anthony P Turner, Naresh Magan
Aug 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wolfram MiekischGabriele F E Noeldge-Schomburg
Dec 15, 2005·Parasitology International·Thomas RomigUte Mackenstedt
Apr 14, 2007·Biomedical Chromatography : BMC·Bogusław BuszewskiAnton Amann
Jun 8, 2007·Emerging Infectious Diseases·Alexander SchweigerPeter Deplazes
Jun 16, 2007·Biochimica Et Biophysica Acta·Gilbert O FruhwirthAlbin Hermetter
Mar 11, 2008·Experimental Parasitology·Alessandra SiracusanoAntonella Teggi
Oct 8, 2009·Nature Nanotechnology·Gang PengHossam Haick
Nov 26, 2009·Acta Tropica·Enrico BrunettiUNKNOWN Writing Panel for the WHO-IWGE
Jun 29, 2010·PLoS Neglected Tropical Diseases·Paul R TorgersonNatalie Ragland
May 1, 2012·Trends in Parasitology·Rebecca K DavidsonLucy J Robertson
Jun 24, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Morad K NakhlehZaid Abassi
Jul 12, 2014·Annual Review of Analytical Chemistry·Anton AmannTerence Risby
Aug 28, 2014·International Journal of Cancer. Journal International Du Cancer·Haitham AmalHossam Haick
Feb 19, 2017·Advances in Parasitology·P KernD A Vuitton
Nov 8, 2017·World Journal of Hepatology·Nikica M GruborYehuda Shoenfeld

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved