PMID: 9183485May 1, 1997Paper

Diagnosis of hypoglycaemia: effects of blood sample handling and evaluation of a glucose photometer in the low glucose range

Acta Paediatrica
A ElimamC Marcus

Abstract

Hypoglycaemia is a dangerous condition. Rapid and reliable blood glucose measurements are necessary for the initiation of treatment to reduce the risk of neurological sequelae. The aim of this study was to compare a bedside glucose photometer (HemoCue) with three methods of handling blood glucose measurements in a routine chemistry laboratory and to estimate the reliability of glucose measurements in the low glucose range during controlled hypoglycaemia. Nine children underwent an arginine-insulin tolerance test as part of a growth hormone deficiency investigation. Only blood samples below 4.0 mmol l-1 were included (n = 35). Significant (0.3-1.0 mmol l-1) differences in blood glucose measurements were found, depending on the handling of the blood sample. The differences seem primarily to be due to glycolysis which occurred in spite of the addition of the glycolysis inhibitor NaF to the blood samples. Immediate centrifugation and analysis of the supernatant or immediate analysis with the HemoCue results in higher, and presumably more correct, values than routine procedures and permits a more accurate diagnosis of hypoglycaemia.

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Citations

Jul 6, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E HagmanR W Holl
Apr 12, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·L Ødum, K Kynde
Mar 26, 2002·Diabetes Technology & Therapeutics·M C TorjmanK Crothall
Jul 10, 2010·Diabetes Technology & Therapeutics·Alper SonmezMustafa Kutlu
Jun 15, 2010·Early Human Development·Kathryn Beardsall
Aug 1, 2009·Diabetes Research and Clinical Practice·Daniela ElleriRoman Hovorka
Mar 1, 2008·Journal of Diabetes Science and Technology·Arjunan GaneshJeffrey Joseph
May 25, 2007·European Journal of Clinical Nutrition·J AlkénC Marcus
Aug 9, 2007·The Journal of Clinical Endocrinology and Metabolism·Claude MarcusJan Gustafsson
May 16, 2012·Journal of Clinical Laboratory Analysis·Elizebeth A FrankCletus J M D'Souza
Apr 21, 1998·Annals of Clinical Biochemistry·K Raile, G Simbruner

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