PMID: 9542783May 30, 1998Paper

Diagnosis of idiopathic myositis: value of 99mtechnetium pyrophosphate muscle scintigraphy and magnetic resonance imaging in targeted muscle biopsy

Rheumatology International
J von KempisH H Peter

Abstract

Our objective was to study the value of 99mtechnetium-pyrophosphate (99mTc-PYP) muscle scintigraphy and magnetic resonance imaging (MRI) in detecting areas of likely muscle inflammation and in increasing the rate of positive muscle biopsies in patients with suspected myositis. The results showed that in 13 out of 13 patients with clinical and/or signs of inflammatory muscle disease, increased 99mTc-PYP uptake was demonstrated at different muscle sites 3 h after isotope injection. Subsequent MRI of symmetric muscle areas with enhanced 99mTc-PYP uptake revealed signal patterns suggesting inflammation in all cases. Biopsy of these targeted muscles demonstrated characteristic histopathologic signs of muscle inflammation in 9 out of 13 patients. Four of these 9 patients had clinically atypical disease or did not show elevated creatine phosphokinase levels. Seven of these 9 patients had not been pretreated with corticosteroids. In 4 patients only muscle fiber atrophy and/or necrosis without cellular infiltrations was seen. These 4 patients had received either high doses of corticosteroids or low doses over longer periods of time before muscle biopsy. In conclusion, the combination of 99mTc-PYP muscle scintigraphy and MRI demonstrated...Continue Reading

Citations

Jun 27, 2008·Clinical Nuclear Medicine·Manuel DafotakisGereon R Fink
Jul 29, 2000·Ultrastructural Pathology·L de PalmaC Bertoni-Freddari
Dec 17, 2014·Clinical Rheumatology·Young-Sil AnHyoun-Ah Kim
Oct 1, 2008·Manual Therapy·Jacek CholewickiElizabeth A Calle
Feb 9, 2000·Rheumatology·I Lundberg, Y Chung
Dec 10, 2017·EJNMMI Research·Karin Folmer ThøgersenLouise Pyndt Diederichsen
Jan 1, 2003·Rheumatic Diseases Clinics of North America·Lisa G Rider

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