PMID: 6989332May 1, 1980Paper

Diagnosis of impaired renal function after kidney transplantation using renal scintigraphy, renal plasma flow and urinary excretion of hippurate

Annals of Surgery
A G DiethelmW N Tauxe

Abstract

The use of 131I-orthiodohippurate (OIH) scintigraphy combined with the estimated renal plasma flow (ERPF) and excretion index (EI) has been beneficial in separating impaired renal function due to graft rejection from acute tubular necrosis, ureteral obstruction, urinary extravasation and in some instances renal artery occlusion. The radionuclide data accurately identified acute and chronic rejection, confirmed by the clinical course, increase in BUN and serum creatinine and on occasion renal biopsy. Reversible and irreversible acute tubular necrosis (ATN) were clearly differentiated from acute rejection. When the ERPF and EI were plotted on a graph, multiple sequential radionuclide studies accurately predicted graft survival when chronic rejection existed. The limitation of this technique was the inability to discriminate between renal artery stenosis, ureteral obstruction and inflammatory disease. Scintigraphic studies did not distinguish between renal artery stenosis and chronic rejection. In these circumstances arteriography was the diagnostic procedure of choice. Although ureteral obstruction often can be correctly diagnosed by scintigrams, the ERPF, EI and intravenous pyelogram remained the most accurate diagnostic procedu...Continue Reading

References

Jan 1, 1977·Scandinavian Journal of Urology and Nephrology·J H KristiansenV Svendsen
Jun 1, 1977·Archives of Internal Medicine·E V DubovskyW N Tauxe
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Citations

Jun 28, 2000·Urology·H SperlingH Rübben
Jan 9, 1999·European Journal of Radiology·T A el MaghrabyE K Pauwels
Feb 17, 1983·The New England Journal of Medicine·J J CurtisH P Dustan
Sep 13, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jason N NixonMarguerite T Parisi
Apr 1, 1985·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R G LukeA G Diethelm
Jan 1, 1995·Seminars in Nuclear Medicine·E V DubovskyB Erbas
Mar 11, 2008·Radiologic Clinics of North America·Wei He, Alan J Fischman
Jan 1, 1982·European Journal of Nuclear Medicine·W N TauxeR Rivera

Related Concepts

Graft Rejection
Hippurates
Kidney
Kidney Diseases
Kidney Tubular Necrosis, Acute
Regional Blood Flow
Renal Artery Stenosis
Transplantation, Homologous
Kidney Transplantation

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