Diagnosis of infectious mononucleosis caused by Epstein-Barr virus in infants

Pediatrics International : Official Journal of the Japan Pediatric Society
Sumitaka DohnoH Wakiguchi

Abstract

The diagnosis of infectious mononucleosis (IM) is usually on serologic tests. The responses of anti-Epstein-Barr virus (anti-EBV) antibodies are weak in infants. The authors encountered some IM infants in whom anti-EBV antibodies were undetectable during early stage, although EBV genome was found in their blood. The aim of the present study was therefore to clarify the frequency of anti-EBV-antibody negative IM cases. The EBV serostatus of 104 IM children diagnosed on Sumaya criteria was retrospectively studied. The EBV genome in peripheral blood mononuclear cells was measured. The anti-viral capsid antigen-IgM (anti-VCA-IgM)-positive rate in the acute phase was only 25% in infants but 80% in patients ≥ 4 years of age. Twenty percent of the infants were negative for all anti-EBV antibodies and required repeated serologic tests. For infants, the significant rise in anti-VCA-IgG was the most sensitive marker. Three seronegative infants with IM symptoms, with circulating EBV genome during acute phase, were eventually considered as having IM on anti-VCA-IgG seroconversion thereafter. To diagnose IM in infants the serologic test alone in the acute phase is not sensitive enough. It is proposed that the EBV genome be evaluated in peri...Continue Reading

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Citations

Oct 1, 2013·International Journal of Dermatology·Vito Di Lernia, Yasaman Mansouri
Jan 19, 2013·Pediatric Hematology and Oncology·Shaza S A MahmoudRyo Sumazaki
Jun 3, 2015·Jundishapur Journal of Microbiology·Mahsa MoeiniMohammad Amin Behzadi
Nov 30, 2011·Current Opinion in Hematology·Evridiki K VouloumanouMatthew E Falagas
Oct 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ebba SohlbergEva Sverremark-Ekström
Dec 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Rabporn SuntornlohanakulYong Poovorawan

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