Diagnosis of intraocular lymphoma by flow cytometry

American Journal of Ophthalmology
J L DavisP Ruiz

Abstract

To evaluate flow cytometry of vitreous cellular specimens as a means of diagnosing intraocular lymphoma and ocular inflammatory disease. We undertook a retrospective, observational study of hematopoietic cell-surface markers in 20 patients with vitreous cellular infiltration in whom lymphoma was considered in the differential diagnosis. Immunophenotyping of vitreous cells obtained by vitrectomy was performed by flow cytometry using antibodies directed against specific cell-surface antigens, including ones associated with B-lymphocyte and T-lymphocyte lymphomas and activated inflammatory cells. Smears were examined cytologically. Cytofluorography was compared with the cytopathologic diagnosis and with final diagnosis. With flow cytometry, a diagnosis of intraocular lymphoma was confirmed in two of four patients with known lymphoma, one of whom had recurrent disease after radiation, and not confirmed in two patients who had had prior treatment with radiation or corticosteroids. In six patients with no prior diagnosis of lymphoma, five were diagnosed with lymphoma on the basis of cytofluorography. Thus, seven (70%) of 10 patients with intraocular lymphoma were diagnosed by cytofluorography compared with three (30%) of 10 with lymp...Continue Reading

References

Dec 1, 1975·Archives of Ophthalmology·R G MichelsW R Green
Dec 1, 1988·The British Journal of Ophthalmology·D H CharT R Miller
Feb 15, 1988·American Journal of Ophthalmology·S de BustrosB M Glaser
Jul 1, 1985·Klinische Monatsblätter für Augenheilkunde·K Lucke, H Laqua
Jul 15, 1984·American Journal of Ophthalmology·M Toledo de AbreuM A Scheinberg
Jan 1, 1981·Retina·H M EngelY S Erozan
Mar 1, 1982·Archives of Ophthalmology·R BelfortN F Mendes
Jan 1, 1981·Retina·D M Carroll, R M Franklin
Aug 1, 1993·Cancer·K PetersonL M DeAngelis

❮ Previous
Next ❯

Citations

Jun 26, 2014·Medical Oncology·Yamin LaiDingrong Zhong
Mar 29, 2002·Survey of Ophthalmology·Russell W ReadNarsing A Rao
Nov 27, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sarah E CouplandNikolaos E Bechrakis
Apr 5, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sarah E CouplandHarald Stein
May 24, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sarah E CouplandHeinrich Heimann
Jul 20, 2012·Ophthalmology·Kentaro KojimaShigeru Kinoshita
Jul 3, 2003·Clinical Lymphoma·Adilia Hormigo, Lisa M DeAngelis
Jul 31, 2007·American Journal of Ophthalmology·Carmen J CalfaJanet L Davis
May 19, 2007·Ophthalmology·Ron MargolisJonathan E Sears
Jul 9, 2004·British Journal of Haematology·Adília HormigoLisa M DeAngelis
Sep 8, 2004·Ophthalmology·Renzo A ZaldivarHans E Grossniklaus
Nov 29, 2005·American Journal of Ophthalmology·Janet L DavisPhillip Ruiz
Aug 9, 2005·Hematology/oncology Clinics of North America·Grace A Levy-ClarkeRobert B Nussenblatt
Apr 16, 2016·Ocular Immunology and Inflammation·Andrea OleñikFrancisco J Muñoz-Negrete
Apr 1, 2012·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Arun D Singh, Charles V Biscotti
Feb 25, 2014·Survey of Ophthalmology·Mandeep S SagooSue Lightman
Feb 24, 2015·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·N StübigerU Pleyer
Jul 9, 2009·Ocular Immunology and Inflammation·H Nida SenRobert Nussenblatt
May 4, 2012·Leukemia·J J M van DongenUNKNOWN EuroFlow Consortium (EU-FP6, LSHB-CT-2006-018708)
Jan 22, 2019·American Journal of Hematology·Macarena I de la FuenteIzidore S Lossos
May 31, 2017·Asia-Pacific Journal of Ophthalmology·Iguaracyra Araujo, Sarah E Coupland
May 31, 2017·Asia-Pacific Journal of Ophthalmology·Mark P GhassibiSander R Dubovy
Mar 13, 2014·International Ophthalmology Clinics·Abdallah Jeroudi, Steven Yeh
Apr 18, 2001·Current Opinion in Oncology·R R BuggageR B Nussenblatt
Feb 10, 2016·Current Opinion in Ophthalmology·David Reichstein
Mar 24, 2016·Ocular Immunology and Inflammation·Florence ChaputLaure E Caspers
Mar 29, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·D Jaehne, S E Coupland
Jun 14, 2006·International Ophthalmology Clinics·Mark R Melson, Shizuo Mukai
May 23, 2014·European Journal of Ophthalmology·Tingting JiangQing Chang
Jul 29, 2020·Frontiers in Immunology·Atsunobu TakedaKoh-Hei Sonoda
Mar 15, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Takako ItoKoh-Hei Sonoda
May 20, 2020·The British Journal of Ophthalmology·Ester CarreñoNicolas Alejandre
Nov 21, 2002·Current Opinion in Ophthalmology·Chi-Chao ChanRobert B Nussenblatt
Sep 21, 2004·Cancer Control : Journal of the Moffitt Cancer Center·Chi-Chao Chan, Dana J Wallace

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.