Diagnosis of mild Alzheimer disease through the analysis of eye movements during reading

Journal of Integrative Neuroscience
Gerardo FernándezOsvaldo Agamennoni

Abstract

Reading requires the integration of several central cognitive subsystems, ranging from attention and oculomotor control to word identification and language comprehension. Reading saccades and fixations contain information that can be correlated with word properties. When reading a sentence, the brain must decide where to direct the next saccade according to what has been read up to the actual fixation. In this process, the retrieval memory brings information about the current word features and attributes into working memory. According to this information, the prefrontal cortex predicts and triggers the next saccade. The frequency and cloze predictability of the fixated word, the preceding words and the upcoming ones affect when and where the eyes will move next. In this paper we present a diagnostic technique for early stage cognitive impairment detection by analyzing eye movements during reading proverbs. We performed a case-control study involving 20 patients with probable Alzheimer's disease and 40 age-matched, healthy control patients. The measurements were analyzed using linear mixed-effects models, revealing that eye movement behavior while reading can provide valuable information about whether a person is cognitively imp...Continue Reading

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Citations

Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Gerardo FernándezNora P Rotstein
Oct 8, 2015·Journal of Integrative Neuroscience·Hassan Zanganeh Momtaz, Mohammad Reza Daliri
Aug 1, 2015·Psychiatry Research·Gerardo FernándezOsvaldo Agamennoni
May 29, 2016·Psychiatry Research·Gerardo FernándezOsvaldo Agamennoni
Jan 13, 2017·Journal of Integrative Neuroscience·G FernándezO Agamenonni
Nov 8, 2018·PloS One·Angela Jinsook OhYaping Joyce Liao
Dec 8, 2015·Current Opinion in Neurology·Michael R MacAskill, Tim J Anderson
Oct 31, 2017·Journal of Integrative Neuroscience·Elena L TeslenkoBoris K Baziyan
Jun 12, 2018·Computational and Mathematical Methods in Medicine·Jessica BeltránJean-François Dartigues
Nov 16, 2021·Seminars in Ophthalmology·Gemma Almario, David P Piñero

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