Diagnosis of Mild Cognitive Impairment Due to Alzheimer's Disease with Transcranial Magnetic Stimulation

Journal of Alzheimer's Disease : JAD
Alessandro PadovaniBarbara Borroni

Abstract

Considering the increasing evidence that disease-modifying treatments for Alzheimer's disease (AD) must be administered early in the disease course, the development of diagnostic tools capable of accurately identifying AD at early disease stages has become a crucial target. In this view, transcranial magnetic stimulation (TMS) has become an effective tool to discriminate between different forms of neurodegenerative dementia. To determine whether a TMS multi-paradigm approach can be used to correctly identify mild cognitive impairment (MCI) due to AD (AD MCI). A sample of 69 subjects with MCI were included and classified as AD MCI or MCI unlikely due to AD (non-AD MCI) based on 1) extensive neurological and neuropsychological evaluation, 2) MRI imaging, and 3) cerebrospinal fluid analysis or/and amyloid PET imaging. A paired-pulse TMS multi-paradigm approach assessing short interval intracortical inhibition-facilitation (SICI-ICF), dependent on GABAergic and glutamatergic intracortical circuits, respectively, and short latency afferent inhibition (SAI), dependent on cholinergic circuits, was performed. We observed a significant impairment of SAI and unimpaired SICI and ICF in AD MCI as compared to non-AD MCI. According to ROC cu...Continue Reading

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Citations

Feb 6, 2019·Current Opinion in Neurology·Stephanie S BussAlvaro Pascual-Leone
Jan 30, 2020·International Journal of Molecular Sciences·Luisa GallaElisa Greotti
Aug 18, 2020·Journal of Alzheimer's Disease : JAD·Alberto BenussiBarbara Borroni
Dec 31, 2019·Journal of Alzheimer's Disease : JAD·Alberto BenussiBarbara Borroni
Apr 16, 2019·Frontiers in Neuroscience·Alberto BenussiBarbara Borroni
Sep 20, 2018·Alzheimer's Research & Therapy·Alberto BenussiBarbara Borroni
Sep 10, 2019·JIMD Reports·Alberto BenussiBarbara Borroni
Jul 3, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Alberto BenussiBarbara Borroni
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Jan 17, 2021·Brain Stimulation·Alberto BenussiBarbara Borroni
Nov 24, 2020·Frontiers in Neurology·Vishal RawjiLorenzo Rocchi
Jan 16, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Donato ColellaMatteo Bologna
Mar 27, 2021·Frontiers in Neurology·Alan J PearceMichael E Buckland
Apr 2, 2021·Journal of Experimental Pharmacology·Marcello GiuntaAlberto Benussi
Jul 3, 2021·Journal of Clinical Medicine·Jakub AntczakAgnieszka Słowik

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