Diagnosis of Newly Delivered Mothers for Periodontitis with a Novel Oral-Rinse aMMP-8 Point-of-Care Test in a Rural Malawian Population

Diagnostics
Jussi M LeppilahtiTimo Sorsa

Abstract

A novel qualitative point-of-care test of activated matrix metalloproteinase-8 (aMMP-8) using noninvasive oral rinse sampling procedures has been developed for the early detection of collagen breakdown indicating periodontal tissue destruction. The main object of this study was to assess the reliability of the test in a low-income setting to identify participants with history of periodontal destruction detected as alveolar bone loss (ABL) in radiographs. This cross-sectional study included 486 women who had recently delivered in rural Malawi. The aMMP-8 test and dental panoramic radiographs were taken within 48 h of delivery. The performance of the test in comparison to radiological examinations was tested by following the standards for reporting of diagnostic accuracy studies protocol (STARD) with respective statistical measures and 95% confidence intervals. From the 486 eligible participants, 461 mothers with complete data, aged from 15 to 46 years (mean 24.8, SD 6.0) were included in the analysis. ABL was identified in 116 of 461 participants. There was 56% agreement between the aMMP-8 test results and detected ABL (yes or no) in radiographs. Calculated sensitivity of the test was 80% (72⁻87%), specificity 48% (43⁻54%), posi...Continue Reading

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Citations

Jul 20, 2019·Journal of Periodontal Research·Ishita BhavsarMohanad Al-Sabbagh
May 17, 2019·Clinical Oral Investigations·Gerd-Jan BoelenGhislain Opdenakker
May 18, 2021·Journal of Clinical Periodontology·Ke DengMaurizio S Tonetti
Sep 2, 2021·Expert Review of Proteomics·Timo SorsaKrishan Gauba

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Methods Mentioned

BETA
pregnancy test
X-ray

Software Mentioned

MiTeeth

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