Diagnosis of pituitary tumors by hormone assays and computerized tomography

The American Journal of Medicine
L J ValentaA N Elias

Abstract

One hundred and seventy patients with endocrine abnormalities, 29 males and 141 females, were studied by computerized tomography (CT) scanning of the pituitary and by pituitary hormone assays including basal and stimulated hormone concentrations in the blood. Pituitary macroadenoma was observed in 40 of the 170 patients, microadenoma in 49, primary empty sella in 46, secondary empty sella in 25, including 20 of the 40 patients with macroadenoma after surgical removal or radiation therapy of the tumor. Suprasellar tumor was present in four patients. In 23 women with menstrual abnormalities and 3 men with impotence and hyperprolactinemia, the results of CT scanning were normal. Of the 40 patients with macroadenoma, 24 presented with a hyperfunctioning syndrome (acromegaly or hyperprolactinemia). Among the 49 patients with microadenomas, 46 had the amenorrhea-galactorrhea syndrome, one male presented with acromegaly and one with Cushing's disease, and one female also had Cushing's disease. Primary empty sella was associated with the amenorrhea-galactorrhea syndrome in females and impotence in males. Only four female patients demonstrating an empty sella were asymptomatic. Distinctive biochemical findings were identified in certain...Continue Reading

References

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Citations

Jan 1, 1989·European Journal of Applied Physiology and Occupational Physiology·A N EliasR Kayaleh
Nov 1, 1983·Clinics in Endocrinology and Metabolism·R P Lamberton, I Jackson
May 12, 1984·British Medical Journal·J P Sheehan, D A Sisam
Oct 1, 1983·The American Journal of Medicine·A M FleckmanN Fleischer
May 1, 1986·Journal of Adolescent Health Care : Official Publication of the Society for Adolescent Medicine·S S Allen, K M Saxena
Dec 1, 1985·British Journal of Obstetrics and Gynaecology·C Ferrari, P G Crosignani

Related Concepts

Adenoma, Trabecular
Differential Diagnosis
Empty Sella Syndrome, Primary
Endocrine System Diseases
Hormones
Neoplasm Recurrence, Local
Pituitary Carcinoma
Radioimmunoassay
Tomography, X-Ray Computerized Axial

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