Diagnosis of pneumocystis pneumonia using serum (1-3)-β-D-Glucan: a bivariate meta-analysis and systematic review

Journal of Thoracic Disease
Wei-Jie LiJin-Liang Kong

Abstract

The (1-3)-β-D-Glucan (BG) assay has been approved for making a diagnosis of invasive fungal disease. However, the role of serum-BG assay for the diagnosis of pneumocystis pneumonia (PCP) is controversial, especially between patients with human immunodeficiency virus (HIV) and non-HIV. We conducted a meta-analysis to determine the difference of the overall accuracy of serum-BG assay for the diagnosis of PCP in immunocompromised patients with and without HIV. After a systematic review of English-language studies and manual researching, sensitivity (Se), specificity (Sp), and other measures of accuracy of serum-BG for the diagnosis of PCP were pooled using random-effects models for bivariate meta-analysis. Summary receiver operating characteristic (SROC) curve was used to summarize overall test performance. Subgroup analyses were performed to explore the heterogeneity in Se and Sp. Thirteen studies met our inclusion criteria. The summary estimates for serum-BG assay for definite PCP were as follows: Se, 0.91 [95% confidence interval (CI), 0.88-0.93]; Sp, 0.75 (95% CI, 0.68-0.81). As for the patients with and without HIV, the Se and Sp were 0.92 and 0.78, 0.85 and 0.73, respectively. Significant heterogeneity between Se was present...Continue Reading

Citations

May 4, 2018·Journal of Clinical Microbiology·Karl DichtlJohannes Wagener
Jun 15, 2018·Clinical Microbiology Reviews·Liang MaJoseph A Kovacs
Aug 23, 2019·Journal of Clinical Microbiology·Gabriela Corsi-VasquezPaul E Sax
May 5, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Yan-Hui ChenLong-Hua Hu

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