Diagnosis of preeclampsia and fetal growth restriction with the sFlt-1/PlGF ratio: Diagnostic accuracy of the automated immunoassay Kryptor®

Pregnancy Hypertension
Lisa Antonia DrögeFrank H Perschel

Abstract

We aimed to characterize the diagnostic accuracy of the Kryptor® assay for sFlt-1 and PlGF in maternal serum samples of uneventful singleton pregnancies and subjects with preeclampsia (PE) and PE-related outcomes such as fetal growth restriction (FGR). Longitudinal reference ranges of the sFlt-1 and PlGF level in the course of normal pregnancies were generated. A cohort of subjects with PE and PE-related outcomes including FGR in the third trimester was compared to a cohort of women with uneventful outcome. Serum levels of sFlt-1, PlGF level as well as the sFlt-1/PlGF ratio was analysed with the Kryptor® assay and compared between the case- and control groups. Cut-off values were generated and diagnostic accuracy examined. Longitudinal reference ranges of the sFlt-1 and PlGF level in healthy pregnancies were in line with those levels measured with other immunoassays. Comparison of the sFlt-1/PlGF ratio between PE-related outcomes including FGR or PE and healthy controls showed a high diagnostic accuracy with an area under the curve (AUC) of 0.917 for PE-related outcomes and 0.919 for PE.

Citations

Jul 20, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Holger StepanDietmar Schlembach
Dec 28, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jennifer L SonesNataki C Douglas
May 13, 2020·The Journal of Applied Laboratory Medicine·Kaspar RatnikMaris Laan
Mar 2, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Pacifique LévyGuillaume Lefèvre
May 16, 2021·American Journal of Obstetrics & Gynecology MFM·Gabriel A ArenasSarosh Rana
Oct 2, 2020·American Journal of Obstetrics and Gynecology·Stefan Verlohren, Lisa-Antonia Dröge
Aug 31, 2021·Journal of the American Heart Association·Lise Lotte Torvin AndersenMartin Overgaard

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