PMID: 8953678Jan 1, 1996Paper

Diagnosis of pulmonary infections in immunocompromised patients by fiber-optic bronchoscopy with bronchoalveolar lavage and serology

Scandinavian Journal of Infectious Diseases
B M ErikssonE Olding-Stenkvist

Abstract

Fiber-optic bronchoscopy (FOB) and bronchoalveolar lavage (BAL) were performed on 67 occasions in 57 immunocompromised patients with symptoms consistent with pulmonary infection. Diagnosis was achieved more often in renal transplant patients than in patients with hematological malignancies (85% versus 28%). Culture (bacteria, virus, fungi), staining and microscopy (bacteria, fungi, Pneumocystis carinii (PC)) and antigen detection by indirect immunofluorescence (cytomegalovirus (CMV), respiratory viruses, PC, Legionella) were used for diagnosis. On 20 occasions transbronchial biopsies with histopathologic examination were performed. In addition, serology comprising the herpes group (HHV-6) and respiratory viruses was done. A microbial diagnosis was obtained on 45% of occasions. The most common pathogens found were CMV (31%) and PC (25%). On 22 (33%) occasions a rapid diagnosis of 1 or more microbial agents was obtained within 24 h by conventional staining or indirect immunofluorescence. The clinical relevance of findings of CMV, HHV-6, and Epstein-Barr virus in BAL by polymerase chain detection on 18, 6 and 3 occasions is discussed. On 4 occasions pathogenic bacteria were found. It was not possible to relate findings of coagulas...Continue Reading

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Citations

May 6, 2009·Annals of Hematology·Dagmar KuehnhardtJan Eucker
Jun 7, 2005·Diagnostic Microbiology and Infectious Disease·Alfred Lennart BissingerHolger Hebart
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·F ReichenbergerM Tamm
Mar 7, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Emilia HardakIlana Oren
Mar 29, 2011·Transplantation Proceedings·E KupeliM Haberal
May 12, 2010·Journal of Applied Microbiology·S FrickeA C Rodloff
Jul 13, 2001·Infectious Disease Clinics of North America·B A Cunha

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