Diagnosis of suspected Alzheimer's disease is improved by automated analysis of regional cerebral blood flow

European Journal of Nuclear Medicine and Molecular Imaging
Bich-Ngoc-Thanh TangThierry Vander Borght

Abstract

Accurate diagnosis of Alzheimer's disease (AD), the most common form of dementia, remains difficult. In order to assess whether fully automated stereotactic surface projection (3D-SSP) presentation contributes to the diagnosis of AD by single-photon emission computed tomography (SPECT), we investigated the diagnostic accuracy of transaxial display with and without 3D-SSP analysis as well as the correlation between cerebral perfusion in different cortical areas and the mini mental score (MMS). Seventy-two patients referred because of cognitive impairment were included in the study. According to the National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) and the Alzheimer's disease and Related Disorders Association (ADRDA) criteria, 27 patients were diagnosed as having probable AD while 45 were classified as non-AD patients. 3D-SSP was used to quantify the regional cerebral blood flow (rCBF) acquired from SPECT imaging. Compared with the transaxial section presentation alone, 3D-SSP presentation improved the area under the receiver operating curve (p<0.05) as well as intra-observer (k=0.73 vs 0.88) and inter-observer (k=0.50 vs 0.84) reproducibility. Upon normalisation of regional to thalamic activity, ...Continue Reading

References

Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A J MartinR S Frackowiak
Sep 1, 1986·Investigative Radiology·C E Metz
Dec 16, 1996·Annals of the New York Academy of Sciences·G W SmallA D Roses
Oct 22, 1998·Neurology·W J JagustJ L Eberling
Mar 10, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·M B ImranH Fukuda
May 14, 1999·Journal of the American Geriatrics Society·A LimE B Larson
May 20, 2000·Annals of the New York Academy of Sciences·K NagataJ Hatazawa
Dec 15, 2000·Psychiatry Research·G RodriguezF Nobili
Mar 13, 2001·Dementia and Geriatric Cognitive Disorders·M Sjöbeck, E Englund
Oct 13, 2001·Dementia and Geriatric Cognitive Disorders·M SteinlingP Charpentier
Nov 28, 2001·Alzheimer Disease and Associated Disorders·L E HebertD A Evans
Apr 27, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Sean J CollobyJohn T O'Brien
Aug 23, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Eva ElghLars Nyberg
Nov 6, 2002·Journal of the Neurological Sciences·Raj Kalaria
Mar 4, 2003·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Stephen J BartelsAnne C Voss
Mar 14, 2003·Archives of Neurology·Dag AarslandPer Kragh-Sørensen
Oct 22, 2003·Journal of the Neurological Sciences·Kazunari IshiiEtsuro Mori

❮ Previous
Next ❯

Citations

Nov 26, 2011·Biochimica Et Biophysica Acta·Anton ForsbergAgneta Nordberg
Aug 9, 2006·Nuclear Medicine Communications·Daniel von BorczyskowskiRalph Buchert
Nov 18, 2009·Nuclear Medicine Communications·Daniel CookeDavid Lewis
Feb 3, 2012·Clinical Physiology and Functional Imaging·Douglas HägerströmLars Edenbrandt
Mar 22, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Daniela D MaltaisVal J Lowe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.