PMID: 11329729May 2, 2001Paper

Diagnosis of the early phase of larval toxocariasis using IgG avidity

Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceské lékarské spolecnosti J.E. Purkyne
J HübnerM Leissová

Abstract

The term avidity used to express the strength of the bond between a serum specimen and a multivalent antigen. It is known that the avidity increases with time after antibody challenge and measurement of the avidity has been used diagnostically. Recently an assay measuring the IgG avidity of various virus infections and of toxoplasmosis was used to distinguish between acute and chronic infection. Our study was focused on the method to distinguish acute and chronic Toxocara infection, zoonosis caused by the larvae of dog and cat ascarids Toxocara canis and Toxocara cati known all over the world for the possibility of provoking the infestation of man, accompanied by visceral or ocular clinical manifestations. The infection is generally diagnosed by demonstration of specific immunoglobulins to Toxocara excretory-secretory antigens (TES) in sera of infected patients. Highly sensitive assays with specific antigens are necessary for detection of antibodies. The test that has been proved clinically useful is the ELISA reaction with TES antigens. This method detects the antibodies for months or even years after infection and this is the reason why the discrimination between chronic and recent infection is very difficult. For disrupting ...Continue Reading

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