Diagnosis of Tuberculosis in HIV Co-infected Individuals: Current Status, Challenges and Opportunities for the Future

Scandinavian Journal of Immunology
P Méndez-Samperio

Abstract

Tuberculosis (TB) remains one of the most important causes of death among people co-infected with human immunodeficiency virus (HIV). The diagnosis of TB remains challenging in HIV co-infected individuals, due to a high frequency of smear-negative disease and high rates of extrapulmonary TB. Accurate, ease of use and rapid diagnosis of active TB are critical to the World Health Organization (WHO) End TB Strategy by 2050. Traditional laboratory techniques do not provide rapid and accurate results to effectively manage HIV co-infected patients. Over the last decade, molecular methods have provided significant steps in the fight against TB. However, many HIV co-infected patients do not have access to these molecular diagnostic tests. Given the costs closely related with confirming a TB diagnosis in HIV patients, an overtreatment for TB is used in this patient population. Nowadays, an estimated US $8 billion a year is required to provide TB treatment, which is very high compared with making an important strategy to improve the current diagnostic tests. This review focuses on current advances in diagnosing active TB with an emphasis on the diagnosis of HIV-associated TB. Also discussed are the main challenges that need to be overcom...Continue Reading

References

Aug 26, 2006·The Lancet Infectious Diseases·Karen R SteingartMadhukar Pai
Sep 30, 2006·The Lancet Infectious Diseases·Karen R SteingartMadhukar Pai
Sep 10, 2010·The New England Journal of Medicine·Catharina C BoehmeMark D Perkins
Apr 16, 2011·American Journal of Respiratory and Critical Care Medicine·Grant TheronKeertan Dheda
Feb 22, 2013·The New England Journal of Medicine·Alimuddin ZumlaC Fordham von Reyn
Mar 28, 2013·The Lancet Infectious Diseases·William A WellsMarco Schito
Jul 19, 2013·The New England Journal of Medicine·Claudio U KöserSharon J Peacock
Aug 13, 2013·Trends in Microbiology·Helen D Donoghue
Jan 17, 2014·The Lancet. Respiratory Medicine·Sven O FriedrichUNKNOWN Pan African Consortium for the Evaluation of Anti-tuberculosis Antibiotics (PanACEA)
Jan 18, 2014·Nature Reviews. Genetics·David SimsChris P Ponting
Jan 28, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Le-yong YuanWan-zhou Xu
Feb 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Emilie LayreD Branch Moody
Mar 26, 2014·Nature Reviews. Genetics·James E Galagan
Apr 4, 2014·The European Respiratory Journal·Claudia M DenkingerKaren R Steingart
May 3, 2014·The New England Journal of Medicine·Suzanne T AndersonBrian Eley
Mar 15, 2015·The Journal of Infectious Diseases·Hugh SalamonDavid L Dolinger
Mar 21, 2015·The European Respiratory Journal·Knut LönnrothMario C Raviglione
Mar 27, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Christian Wejse
Mar 31, 2015·The Lancet. Respiratory Medicine·Anne K DetjenAnna M Mandalakas
May 12, 2015·Annals of Global Health·Amy Y VittorRobert H Gilman
Jun 14, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J H K ChenW-C Yam
Jun 25, 2015·Microbiology Spectrum·Emilie LayreD Branch Moody
Jun 28, 2015·The Lancet Infectious Diseases·Timothy M WalkerUNKNOWN Modernizing Medical Microbiology (MMM) Informatics Group
Oct 16, 2015·The Journal of Experimental Medicine·Jennifer L Gardiner, Christopher L Karp
Oct 18, 2015·The Lancet Global Health·Paul K Drain, Nigel J Garrett
Oct 31, 2015·Lancet·Jennifer FurinSarah Zaidi
Dec 17, 2015·The Lancet. Respiratory Medicine·Louise J PankhurstUNKNOWN COMPASS-TB Study Group

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Citations

Feb 15, 2019·PLoS Neglected Tropical Diseases·Susan L BaldwinRhea N Coler
Jan 25, 2018·The American Journal of Tropical Medicine and Hygiene·Anthony S Fauci, Robert W Eisinger
Nov 30, 2019·Scandinavian Journal of Immunology·Petter Höglund
May 12, 2019·QJM : Monthly Journal of the Association of Physicians·E Mukhametshina, P Gavrilov
Dec 15, 2020·Current Opinion in Infectious Diseases·David V MhangoHenry C Mwandumba
Oct 19, 2020·Médecine et maladies infectieuses·S B GressensF Méchaï

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