Diagnosis of viral myocarditis by cardiac magnetic resonance and viral genome detection in peripheral blood.

The International Journal of Cardiovascular Imaging
Michael JeserichAnnette Geibel

Abstract

In patients with acute myocarditis, viral genome can be detected in plasma and peripheral leukocytes. Its relationship with active myocardial inflammation, however, is not well understood. Myocardial edema as a feature of inflammation and myocardial necrosis or fibrosis can be frequently observed in patients with acute myocarditis by cardiovascular magnetic resonance (CMR). We assessed the association of viral genome presence in peripheral blood samples with myocardial edema and irreversible injury. We examined consecutive patients with clinically suspected myocarditis after an episode of viral illness. State-of-the-art methods were used for detecting myocardial edema and irreversible injury using CMR and viral genome applying reverse transcribed, nested polymerase chain reaction in peripheral blood samples. The specificity of viral amplification products was confirmed by automatic DNA sequencing. Of a total of 55 patients (53.5 ± 15.6 years), 21 were positive for viral genome in peripheral leukocytes. Interestingly, 18 (86%) of these patients also showed global myocardial edema, as compared to only 7/34 (21%) without PCR evidence for viral genome. The overall agreement between CMR criteria for edema and viral PCR was 84%. In c...Continue Reading

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Citations

Apr 2, 2014·The International Journal of Cardiovascular Imaging·Hiram G BezerraNico R L Van de Veire
Nov 13, 2015·Expert Review of Cardiovascular Therapy·Sophie MavrogeniGenovefa Kolovou
Nov 23, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Michael JeserichChristoph Bode
Nov 19, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Puja BankaAndrew J Powell
Oct 1, 2015·Case Reports in Medicine·Mark A WeinreichRobert W Haley
Dec 4, 2014·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Yeonyee E Yoon The Korean Society of Cardiology and the Korean Society of Radiology
Jul 8, 2020·Current Cardiology Reports·Fang TangWei-Feng Yuan
Dec 12, 2020·Signal Transduction and Targeted Therapy·Weijian HangDao Wen Wang

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