Diagnosis, pathogenesis, and treatment of autoimmune hepatitis after liver transplantation.

Digestive Diseases and Sciences
Albert J Czaja

Abstract

Autoimmune hepatitis can recur or appear de novo after liver transplantation, and it can result in hepatic fibrosis, graft loss, and re-transplantation. The goals of this review are to describe the prevalence, manifestations, putative pathogenic mechanisms, outcomes, and management of these occurrences. Autoimmune hepatitis recurs in 8-12 % of transplanted patients at 1 year and 36-68 % at 5 years. Recurrence may be asymptomatic and detected only by surveillance liver test abnormalities or protocol liver tissue examination. Autoantibodies that characterized the original disease, hypergammaglobulinemia, increased serum immunoglobulin G level, and histological findings of interface hepatitis, lymphoplasmacytic infiltration, perivenular hepatocyte necrosis, pseudo-rosetting, and acidophil bodies typify recurrence. Premature corticosteroid withdrawal and pre-transplant severity of the original disease are possible risk factors. De novo autoimmune hepatitis occurs in 1-7 % of patients 0.1-9 years after transplantation, especially in children. The appearance of autoantibodies may herald its emergence, and antibodies to glutathione-S-transferase T1 have been predictive of the disease. Recurrent disease may reflect recruitment of resid...Continue Reading

References

Oct 1, 1991·The Journal of Clinical Investigation·M P MannsE F Johnson
Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L Sanchez-UrdazpalR H Wiesner
Aug 1, 1991·Seminars in Liver Disease·T PorallaB Fleischer
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J QuirogaD H Van Thiel
Apr 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P T DonaldsonR Williams
May 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D K FreeseW D Payne
Jun 1, 1990·Digestive Diseases and Sciences·C KassianidesJ H Hoofnagle
Jun 1, 1990·Human Pathology·J LudwigS B Moore
Nov 3, 1988·Nature·D Gray, H Skarvall
Sep 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J E HegartyR Williams
Aug 1, 1995·Journal of Hepatology·H I HuppertzK H Meyer zum Büschenfelde
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·A R Mclean, C A Michie
Jun 1, 1993·Current Opinion in Immunology·J Sprent
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P J Johnson, I G McFarlane
May 1, 1993·Transplantation·L BäckmanG Klintmalm
Jan 1, 1996·Alimentary Pharmacology & Therapeutics·R Brattsand, M Linden
Jan 27, 1997·Transplantation·G V MazariegosT E Starzl
Feb 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J CzajaR Williams
Feb 1, 1997·Transplantation Proceedings·M AhmedE Elias
Jun 1, 1997·Gastroenterology·M D StrettellR Williams
Jul 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C SempouxJ Rahier
Jul 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·A H BirnbaumN S LeLeiko
Jul 27, 1997·Transplantation·A C TsamandasR G Lee
Oct 27, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M D StrettellR Williams
Oct 27, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M P Manns, P Obermayer-Straub
May 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J DevlinR Williams
Dec 24, 1997·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·P RosenthalL Ferrell
Jan 1, 1997·Seminars in Liver Disease·M Sumiya, J A Summerfield
Mar 3, 1998·Lancet·N KerkarG Mieli-Vergani
Jun 20, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M HayashiC O Esquivel
Jul 22, 1998·Journal of Hepatology·M N Vázquez-GarcíaC Gorodezky
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J Czaja
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H WiesnerK M Detre

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Citations

May 22, 2013·Clinical & Developmental Immunology·Toshiaki NakanoShigeru Goto
Oct 3, 2013·Journal of Hepatology·Marco Carbone, James M Neuberger
Dec 3, 2014·Clinics in Liver Disease·Albert J Czaja
Aug 25, 2012·Digestive Diseases and Sciences·Albert J Czaja
Oct 24, 2012·Digestive Diseases and Sciences·Albert J Czaja
Jul 31, 2013·The Veterinary Clinics of North America. Small Animal Practice·Katrina R Viviano
Jan 19, 2016·Current Gastroenterology Reports·Craig LammertSamer Gawrieh
Feb 13, 2015·Intractable & Rare Diseases Research·Tomohiro TanakaNorihiro Kokudo
Jun 14, 2015·Clinics and Research in Hepatology and Gastroenterology·Jérôme DumortierOlivier Boillot
Sep 7, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M P Manns, H Mix
Jul 3, 2013·Alimentary Pharmacology & Therapeutics·A J Czaja
Oct 12, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoshihide UedaShinji Uemoto
Dec 20, 2014·Clinical Transplantation·Antonella FoschiLuca Saverio Belli
Aug 19, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·John M Vierling
Mar 10, 2015·Frontiers of Medicine·Farhad Sahebjam, John M Vierling
Feb 25, 2017·Clinical Transplantation·Lauri PuustinenMartti Färkkilä
Mar 16, 2018·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
Jun 13, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Eleni Theocharidou, Michael A Heneghan
Oct 31, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Guido StirnimannAldo J Montano-Loza
Oct 16, 2012·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
Oct 16, 2012·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
May 4, 2013·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
Jul 19, 2019·Clinical Liver Disease·Adam VanHuis, Veronica Loy
Jul 16, 2014·World Journal of Hepatology·Marta Casal MouraGuilherme Macedo
Aug 22, 2014·European Journal of Gastroenterology & Hepatology·Douglas GrunwaldRaza Malik
Dec 22, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cara L MackAlbert J Czaja
Jan 1, 2015·Terapevticheskiĭ arkhiv·O S DerevyankoI I Dedov
Jun 6, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·John M VierlingMouaz Alsawas
Aug 10, 2018·World Journal of Gastroenterology : WJG·Isabel AguileraAntonio Nuñez-Roldan
Dec 14, 2016·Alimentary Pharmacology & Therapeutics·A J Montano-LozaA L Mason
May 30, 2019·American Journal of Clinical Pathology·Thomas D SchianoM Isabel Fiel
Dec 31, 2019·Journal of Immunology Research·Elisabeth SucherThomas Berg
Mar 15, 2016·World Journal of Gastroenterology : WJG·Ranka VukoticPietro Andreone
Oct 21, 2020·Clinics and Research in Hepatology and Gastroenterology·Eduardo CouchonnalJérôme Dumortier
Dec 15, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Lin MaLi-Ying Sun
Jun 1, 2021·Journal of the Canadian Association of Gastroenterology·Fernanda de Quadros OnofrioNazia Selzner

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