Diagnostic ability of elevated 1-h glucose challenge test

Journal of Perinatology : Official Journal of the California Perinatal Association
L A TemmingA G Cahill

Abstract

To determine whether a threshold of a 1-h glucose challenge test (GCT) eliminates the need for a 3-h glucose tolerance test (GTT). A retrospective cohort of patients undergoing GTT after GCT was ⩾140 mg dl(-1). Gestational diabetes mellitus (GDM) was diagnosed using National Diabetes Data Group (NDDG) and Carpenter-Coustan (CC) criteria. Sensitivity, specificity and predictive values were calculated for 1-h GCT values of 160 to 220 mg dl(-1). Of 6218 patients, 988 (15.9%) had an elevated GCT and 753 (12.1%) underwent a GTT. In all, 165 (2.7%) were diagnosed with GDM using NDDG criteria, and 250 (4.0%) by CC criteria. The positive predictive value of a 1-h of GCT ⩾200 mg dl(-1) for GDM was 68.6% by NDDG and 80.0% for GDM by CC criteria. Although the predictive value of an elevated 1-h ⩽200 mg dl(-1) for GDM was high, 1 in 3 to 1 in 5 women would be overdiagnosed with GDM if the 3-h GTT was omitted.

References

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Citations

Jan 10, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Misgav RottenstreichHen Y Sela
Aug 14, 2020·Diabetes Research and Clinical Practice·Misgav RottenstreichHen Y Sela
Nov 27, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Salvatore F SfameniAndrew C C Ngu

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