Nov 9, 2019

Diagnostic ability of multifocal electroretinogram in early multiple sclerosis using a new signal analysis method

PloS One
L BoqueteE Garcia-Martin


To determine if a novel analysis method will increase the diagnostic value of the multifocal electroretinogram (mfERG) in diagnosing early-stage multiple sclerosis (MS). We studied the mfERG signals of OD (Oculus Dexter) eyes of fifteen patients diagnosed with early-stage MS (in all cases < 12 months) and without a history of optic neuritis (ON) (F:M = 11:4), and those of six controls (F:M = 3:3). We obtained values of amplitude and latency of N1 and P1 waves, and a method to assess normalized root-mean-square error (FNRMSE) between model signals and mfERG recordings was used. Responses of each eye were analysed at a global level, and by rings, quadrants and hemispheres. AUC (area under the ROC curve) is used as discriminant factor. The standard method of analysis obtains further discrimination between controls and MS in ring R3 (AUC = 0.82), analysing N1 waves amplitudes. In all of the retina analysis regions, FNRMSE value shows a greater discriminating power than the standard method. The highest AUC value (AUC = 0.91) was in the superior temporal quadrant. By analysing mfERG recordings and contrasting them with those of healthy controls it is possible to detect early-stage MS in patients without a previous history of ON.

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Mentioned in this Paper

PRF1 protein, human
Orbital Region
Optic Neuritis
N1, N1-diethyl-N2-(2,3,4,6-tetra-O-acetyl-glucopyranosyl)acetamidine
Cerebral Hemisphere Structure (Body Structure)
Multiple Sclerosis
Plant Roots
Early Diagnosis

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