Diagnostic accuracy and prognostic value of combined dipyridamole-exercise thallium imaging in hemodialysis patients

Kidney International
M DahanF E Mignon

Abstract

Non-invasive detection of coronary artery disease in dialysis patients, a major cause of mortality, often remains difficult. The aim of the study was to test the diagnostic and prognostic accuracies of combined dipyridamole-exercise thallium imaging in dialysis patients. Dipyridamole-exercise thallium imaging and coronary angiography were both performed prospectively in 60 asymptomatic hemodialysis patients who were followed up, long term, by recording any major coronary event. Coronary angiography was abnormal in 13 patients (21%), and there was abnormal thallium uptake in 17 patients. Sensitivity, specificity, positive and negative predictive values, and overall accuracy of thallium to detect a coronary artery disease were 92, 89, 71, 98 and 90%, respectively. After a median follow-up of 2.8 years, 12 patients experienced at least one major coronary event (4 cardiac deaths, 5 myocardial infarctions and 3 revascularizations). Eight of the 17 patients with abnormal thallium uptake (47%) suffered a coronary event, compared to only 4 of the 43 patients (9%) with a normal thallium uptake (P < 0.001). The positive prognostic predictive value of thallium imaging was 47% and its negative predictive value was 91%. The probability of s...Continue Reading

References

Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Jul 1, 1987·Hypertension·D S SchulmanF J Wackers
Apr 1, 1986·Annals of Internal Medicine·C P TaliercioJ C Burnett
Sep 1, 1981·The American Journal of Medicine·E RoigF Navarro-Lopez
Oct 1, 1996·Journal of the American Society of Nephrology : JASN·J A de Lemos, L D Hillis
Jan 1, 1996·Nephron·V Wizemann
Nov 1, 1996·Current Opinion in Nephrology and Hypertension·S W Murphy, P S Parfrey
Nov 1, 1996·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·K A Brown

❮ Previous
Next ❯

Citations

Nov 6, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Masato Nishimura, Toshihiko Ono
May 28, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Tsuguru HattaTsunehiko Nishimura
Jan 16, 2007·International Urology and Nephrology·Lygeri P SoubassiDimitrios A Valis
Mar 25, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Bradley A BartCharles A Herzog
Dec 25, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Robert C HendelUNKNOWN American Society of Nuclear Cardiology
Aug 9, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Frans J Th Wackers
Apr 4, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Tochi Okwuosa, Kim A Williams
Nov 21, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R Parker WardUNKNOWN American Society of Nuclear Cardiology
Jun 8, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D Elsner
Jul 16, 2004·Heart·T M Bateman, E Prvulovich
Feb 2, 2013·Transplantation Research·Jose Jg De LimaFlavio J de Paula
Mar 29, 2008·Journal of the American Society of Nephrology : JASN·Angelo M de MattosAmi E Iskandrian
Apr 16, 2003·The American Journal of the Medical Sciences·Christine M LogarSrinivasan Beddhu
Jan 1, 2013·Kidney International Supplements
Oct 9, 2014·Kidney International·Allyson HartBertram L Kasiske
Oct 1, 2011·Kidney International·An S De VrieseFrank W De Geeter
May 30, 2008·Kidney International·Sikander P SuranaAjay K Singh
Sep 29, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Krista L LentineKevin C Abbott
Jul 28, 2009·International Journal of Cardiology·Paul AtkinsonPhilip A Kalra
Sep 27, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michel DahanFrançoise E Mignon
Dec 4, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Masao MoroiKenjiro Kikuchi
Jan 15, 2009·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Naoyuki HasebeKenjiro Kikuchi
Aug 17, 2006·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Hiroki HaseMasao Moroi
Jun 3, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Sean A EnkiriMichael Ragosta
Sep 17, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M R KahnM J Robbins
Mar 9, 2007·Annales de cardiologie et d'angéiologie·H BenamerC Gaultier
Aug 29, 2006·Current Problems in Cardiology·Raymond R Russell, Barry L Zaret
Oct 9, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kalindi ParikhRami Doukky
Jan 15, 2008·Journal of the American College of Cardiology·Masato NishimuraToshihiko Ono
Jul 6, 2012·Journal of the American College of Cardiology·Krista L LentineUNKNOWN American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Peripheral Vascular Disease
Jul 10, 2016·The American Journal of Cardiology·David M MannRichard A Mann
Aug 5, 2000·Advances in Renal Replacement Therapy·S W Burke, A J Solomon
Dec 14, 2011·The Cochrane Database of Systematic Reviews·Louis W WangAngela C Webster
Feb 3, 2016·Circulation·Marcello TonelliRavi Thadhani
Feb 18, 2004·Hypertension·Charles A Herzog

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.